LEADER 03668nam 2200601 a 450 001 9910437831603321 005 20200520144314.0 010 $a1-283-91087-X 010 $a94-007-5678-X 024 7 $a10.1007/978-94-007-5678-6 035 $a(CKB)2670000000314935 035 $a(EBL)1083615 035 $a(OCoLC)822576858 035 $a(SSID)ssj0000811438 035 $a(PQKBManifestationID)11427907 035 $a(PQKBTitleCode)TC0000811438 035 $a(PQKBWorkID)10850477 035 $a(PQKB)11189912 035 $a(DE-He213)978-94-007-5678-6 035 $a(MiAaPQ)EBC1083615 035 $a(PPN)168341514 035 $a(EXLCZ)992670000000314935 100 $a20121009d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMorphine and metastasis /$fMarie-Odile Parat, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (148 p.) 300 $aDescription based upon print version of record. 311 $a94-007-9296-4 311 $a94-007-5677-1 320 $aIncludes bibliographical references and index. 327 $a1 Morphine and metastasis: from bench to bedside -- 2 Interaction of Naloxone and Estrogen Receptor in Breast Cancer -- 3 Morphine and immunosuppression in the context of tumor growth and metastasis -- 4 Opioid Regulation of Vascular Integrity -- 5 Iatrogenic Angiogenesis -- 6 Could opioids affect cancer recurrence or metastases? Current experimental and Translational Evidence -- 7 Genetic polymorphisms in the µ-opioid receptor gene and breast cancer survival -- 8 Anaesthetic and pain management technique in long term cancer outcome - benefits of regional anaesthesia and analgesia in the context of cancer surgery -- 9 Perioperative morphine and cancer recurrence. 330 $aThe possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. This book combines chapters written by qualified experts around the world whose research encompasses the effect of morphine or other opioids on tumour growth and metastasis. This includes clinicians, researchers working on animal models and studying the effect of morphine on tumours, and most importantly the mechanism for this effect, and lastly cell biologists. Current investigations and cross talk between basic science and clinical trials will refine our understanding of the multiple levels of actions of morphine and other opioids on tumour growth and metastasis, and result in improved guidelines for patient care. This book will be of interest to clinicians, especially those dealing with cancer patients and their pain management, as well as students, teachers and scientists in the fields of anaesthesiology, oncology, tumour biology, immunology, opioid pharmacology. 606 $aMorphine 606 $aMetastasis 606 $aCancer$xChemotherapy 615 0$aMorphine. 615 0$aMetastasis. 615 0$aCancer$xChemotherapy. 676 $a362.2930976399 701 $aParat$b Marie-Odile$01750150 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437831603321 996 $aMorphine and metastasis$94184698 997 $aUNINA