LEADER 03944nam 2200649 a 450 001 9910437830503321 005 20200520144314.0 010 $a1-283-93456-6 010 $a1-62703-164-2 024 7 $a10.1007/978-1-62703-164-6 035 $a(CKB)2670000000316206 035 $a(EBL)1082116 035 $a(OCoLC)823386534 035 $a(SSID)ssj0000810447 035 $a(PQKBManifestationID)11427878 035 $a(PQKBTitleCode)TC0000810447 035 $a(PQKBWorkID)10832649 035 $a(PQKB)10907918 035 $a(DE-He213)978-1-62703-164-6 035 $a(MiAaPQ)EBC1082116 035 $a(PPN)168305992 035 $a(EXLCZ)992670000000316206 100 $a20121017d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAssessing ocular toxicology in laboratory animals /$fAndrea A. Weir, Margaret Collins, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (326 p.) 225 0$aMolecular and integrative toxicology 300 $aDescription based upon print version of record. 311 $a1-62703-897-3 311 $a1-62703-163-4 320 $aIncludes bibliographical references and index. 327 $aComparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye:  Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug. 330 $aOcular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes.  Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.  The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies. 410 0$aMolecular and Integrative Toxicology,$x2168-4219 606 $aOcular toxicology 606 $aVeterinary ophthalmology 606 $aTumors in animals 615 0$aOcular toxicology. 615 0$aVeterinary ophthalmology. 615 0$aTumors in animals. 676 $a617.7 676 $a617.71 701 $aWeir$b Andrea A$01759837 701 $aCollins$b Margaret$01151587 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437830503321 996 $aAssessing ocular toxicology in laboratory animals$94198498 997 $aUNINA