LEADER 03030nam 2200541 a 450 001 9910437830003321 005 20170925231201.0 010 $a1-283-62362-5 010 $a9786613936073 010 $a1-4614-4009-2 024 7 $a10.1007/978-1-4614-4009-3 035 $a(CKB)2670000000246530 035 $a(EBL)1030358 035 $a(OCoLC)810931910 035 $a(SSID)ssj0000767208 035 $a(PQKBManifestationID)11423981 035 $a(PQKBTitleCode)TC0000767208 035 $a(PQKBWorkID)10740688 035 $a(PQKB)10309804 035 $a(DE-He213)978-1-4614-4009-3 035 $a(MiAaPQ)EBC1030358 035 $a(PPN)168299011 035 $a(EXLCZ)992670000000246530 100 $a20120710d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSystems biology of apoptosis /$fInna N. Lavrik, editor 210 $aNew York $cSpringer$d2013 215 $a1 online resource (210 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-4008-4 320 $aIncludes bibliographical references and index. 327 $aPreface -- Modeling formalisms in systems biology of apoptosis -- Systems biology of death receptor-induced apoptosis -- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis -- Systems Biology of the Mitochondrial Apoptosis Pathway -- Systems biology of cell death in hepatocytes -- Understanding different types of cell death using Systems Biology -- Modeling Single Cells in Systems Biology -- Cytokine-cytokine crosstalk and cell-death decisions -- Genetic and genomic dissection of apoptosis signaling -- Index. 330 $aApoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death. In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies. 606 $aApoptosis 615 0$aApoptosis. 676 $a571.936 701 $aLavrik$b Inna N$01058869 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437830003321 996 $aSystems biology of apoptosis$92502955 997 $aUNINA