LEADER 05917nam 22007935 450 001 9910437829103321 005 20250603221618.0 010 $a1-283-84976-3 010 $a94-007-4525-7 024 7 $a10.1007/978-94-007-4525-4 035 $a(CKB)2670000000280557 035 $a(EBL)971828 035 $a(OCoLC)821049506 035 $a(SSID)ssj0000791005 035 $a(PQKBManifestationID)11428982 035 $a(PQKBTitleCode)TC0000791005 035 $a(PQKBWorkID)10748410 035 $a(PQKB)10731017 035 $a(DE-He213)978-94-007-4525-4 035 $a(MiAaPQ)EBC971828 035 $a(PPN)16833822X 035 $a(EXLCZ)992670000000280557 100 $a20121116d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEpigenetics: Development and Disease /$fedited by Tapas Kumar Kundu 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (697 p.) 225 1 $aSubcellular Biochemistry,$x2542-8810 ;$v61 300 $aDescription based upon print version of record. 311 08$a94-007-4524-9 320 $aIncludes bibliographical references and index. 327 $aPART I: EPIGENETICS AND EVOLUTION -- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective -- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure -- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization -- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria -- PART II: DEVELOPMENTAL EPIGENETICS -- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module -- 2.2 Epigenetic regulation of male germ cell differentiation -- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation -- 2.4 Small changes, big effects: chromatin goes aging -- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development -- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION -- 3.1 Basic mechanisms in RNA Polymerase I transcriptionof the ribosomal RNA genes -- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context -- 3.3 RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization -- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans -- 3.5 Histone variants and Transcription regulation -- 3.6 Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View -- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease -- PART IV: EPIGENETICS AND DISEASE -- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology -- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression -- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes -- 4.4 Epigenetic changes in inflammatory and autoimmune diseases -- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication -- 4.6 Epigenetics in Parkinson?s and Alzheimer?s diseases -- 4.7 Cellular Redox, Epigenetics and Diseases -- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY -- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells -- 5.2 Histone acetylation as a therapeutic target- Implication of nanodelivery -- 5.3 DNA methylation and Cancer -- 5.4 Role of epigenetics in inflammation-associated diseases -- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease. 330 $aEpigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience. 410 0$aSubcellular Biochemistry,$x2542-8810 ;$v61 606 $aMolecular genetics 606 $aPost-translational modification 606 $aCancer 606 $aDevelopmental biology 606 $aStem cells 606 $aMolecular Genetics 606 $aPost-translational Modifications 606 $aCancer Biology 606 $aDevelopmental Biology and Stem Cells 606 $aStem Cell Biology 615 0$aMolecular genetics. 615 0$aPost-translational modification. 615 0$aCancer. 615 0$aDevelopmental biology. 615 0$aStem cells. 615 14$aMolecular Genetics. 615 24$aPost-translational Modifications. 615 24$aCancer Biology. 615 24$aDevelopmental Biology and Stem Cells. 615 24$aStem Cell Biology. 676 $a572.865 676 $a616.042 701 $aKundu$b Tapas K$01763998 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437829103321 996 $aEpigenetics$94204734 997 $aUNINA