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010   $a1-283-62448-6
010   $a9786613936936
010   $a1-4614-4815-8
024 7 $a10.1007/978-1-4614-4815-0
035   $a(CKB)2670000000246545
035   $a(EBL)994590
035   $a(OCoLC)811139863
035   $a(SSID)ssj0000767095
035   $a(PQKBManifestationID)11429475
035   $a(PQKBTitleCode)TC0000767095
035   $a(PQKBWorkID)10739886
035   $a(PQKB)11209362
035   $a(DE-He213)978-1-4614-4815-0
035   $a(MiAaPQ)EBC994590
035   $a(PPN)16830127X
035   $a(EXLCZ)992670000000246545
100   $a20120814d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aMicrodialysis in drug development /$fMarkus Muller, editor
205   $a1st ed. 2013.
210   $aNew York $cSpringer$d2013
215   $a1 online resource (341 p.)
225  0$aAAPS advances in the pharmaceutical sciences series,$x2210-7371
300   $aDescription based upon print version of record.
311   $a1-4899-9621-4 
311   $a1-4614-4814-X 
320   $aIncludes bibliographical references and index.
327   $apt. 1. General aspects -- pt. 2. Specific topics.
330   $aIn vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
410  0$aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-7371 ;$v4
606   $aDrug development
606   $aBrain microdialysis
615  0$aDrug development.
615  0$aBrain microdialysis.
676   $a615/.19
676   $a616.8/04754
701   $aMuller$b Markus$0375995
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437827103321
996   $aMicrodialysis in drug development$94184682
997   $aUNINA