LEADER 01111nam0-2200361---450 001 990009725220403321 005 20190117134256.0 010 $a978-88-230-1497-8 035 $a000972522 035 $aFED01000972522 035 $a(Aleph)000972522FED01 035 $a000972522 100 $a20130508d2010----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------101yy 200 1 $aAutunno caldo, quarant'anni dopo$fa cura di Carlo Ghezzi$gcon un intervento inedito di Bruno Trentin 210 $aRoma$cEdiesse$d2010 215 $a133 p.$cill.$d21 cm$e1 DVD-Video 225 1 $aStoria e memoria 300 $aContiene gli atti del convegno tenuto a Roma nel 2009 610 0 $aLotte sindacali$a1969 676 $a331.89$v22$zita 702 1$aGhezzi,$bCarlo$f<1946- > 702 1$aTrentin,$bBruno$f<1926-2007> 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a990009725220403321 952 $aXIV G 298$b49289$fFSPBC 952 $aFONDO SENATO 129$b15/2019$fFSPBC 959 $aFSPBC 996 $aAutunno caldo, quarant'anni dopo$9841721 997 $aUNINA LEADER 04295nam 2200625 a 450 001 9910437826803321 005 20200520144314.0 010 $a1-283-93528-7 010 $a3-642-33570-5 024 7 $a10.1007/978-3-642-33570-9 035 $a(CKB)2670000000317383 035 $a(EBL)1082699 035 $a(OCoLC)823728111 035 $a(SSID)ssj0000830652 035 $a(PQKBManifestationID)11470832 035 $a(PQKBTitleCode)TC0000830652 035 $a(PQKBWorkID)10820329 035 $a(PQKB)11065966 035 $a(DE-He213)978-3-642-33570-9 035 $a(MiAaPQ)EBC1082699 035 $a(PPN)168324873 035 $a(EXLCZ)992670000000317383 100 $a20121022d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBotulinum neurotoxins /$fAndreas Rummel, Thomas Binz, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (321 p.) 225 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$vv. 364 300 $aDescription based upon print version of record. 311 $a3-642-44889-5 311 $a3-642-33569-1 320 $aIncludes bibliographical references and index. 327 $aGenetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes -- Assembly and Function of the Botulinum Neurotoxin Progenitor Complex -- Uptake of Botulinum Neurotoxin in the Intestine -- Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity -- The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go? -- Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons -- Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission -- Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins -- Persistence of Botulinum Neurotoxin Inactivation of Nerve Function -- Structure-Based Drug Discovery for Botulinum Neurotoxins -- Complexity of Botulinum Neurotoxins: Challenges for Detection Technology -- Progress in Cell Based Assays for Botulinum Neurotoxin Detection -- Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics -- Botulinum Toxin: Application, Safety, and Limitations. 330 $aBotulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications. This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies. 410 0$aCurrent topics in microbiology and immunology ;$v364. 606 $aBotulinum toxin 606 $aNeurotoxic agents 615 0$aBotulinum toxin. 615 0$aNeurotoxic agents. 676 $a615.9/5 676 $a615.95 701 $aRummel$b Andreas$01761729 701 $aBinz$b Thomas$01761730 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437826803321 996 $aBotulinum neurotoxins$94201339 997 $aUNINA