LEADER 03226nam  2200577 a 450 
001 9910437826303321
005 20200520144314.0
010   $a3-642-37765-3
024 7 $a10.1007/978-3-642-37765-5
035   $a(CKB)2670000000371225
035   $a(EBL)1317009
035   $a(SSID)ssj0000894398
035   $a(PQKBManifestationID)11472553
035   $a(PQKBTitleCode)TC0000894398
035   $a(PQKBWorkID)10834892
035   $a(PQKB)10091614
035   $a(DE-He213)978-3-642-37765-5
035   $a(MiAaPQ)EBC1317009
035   $a(PPN)170491633
035   $a(EXLCZ)992670000000371225
100   $a20130424d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aIntrinsic immunity /$fBryan R. Cullen, editor ; responsible series editor, Peter K. Vogt
205   $a1st ed. 2013.
210   $aHeidelberg ;$aNew York $cSpringer$dc2013
215   $a1 online resource (264 p.)
225 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$vv. 371
300   $aDescription based upon print version of record.
311   $a3-642-42763-4 
311   $a3-642-37764-5 
320   $aIncludes bibliographical references and index.
327   $aThe APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.
330   $aRecent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.  .
410  0$aCurrent topics in microbiology and immunology ;$vv. 371.
606   $aImmunity
615  0$aImmunity.
676   $a571.9/648
676   $a616.079
701   $aCullen$b Bryan R$01754792
701   $aVogt$b Peter K$075916
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437826303321
996   $aIntrinsic immunity$94191289
997   $aUNINA