LEADER 03814nam 2200625 a 450 001 9910437824103321 005 20200520144314.0 010 $a1-4614-5480-8 024 7 $a10.1007/978-1-4614-5480-9 035 $a(CKB)2670000000277893 035 $a(EBL)1081931 035 $a(OCoLC)819379531 035 $a(SSID)ssj0000798786 035 $a(PQKBManifestationID)11429289 035 $a(PQKBTitleCode)TC0000798786 035 $a(PQKBWorkID)10754630 035 $a(PQKB)10941887 035 $a(DE-He213)978-1-4614-5480-9 035 $a(MiAaPQ)EBC1081931 035 $a(PPN)168303140 035 $a(EXLCZ)992670000000277893 100 $a20120910d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe immunological barriers to regenerative medicine /$fPaul J. Fairchild, editor 205 $a1st ed. 2013. 210 $aNew York $cHumana Press$d2013 215 $a1 online resource (333 p.) 225 0$aStem cell biology and regenerative medicine 300 $aDescription based upon print version of record. 311 $a1-4899-9932-9 311 $a1-4614-5479-4 320 $aIncludes bibliographical references and index. 327 $apt. 1. The immunogenicity of stem cells -- pt. 2. Strategies for overcoming rejection of stem cell grafts -- pt. 3. Induction of immunological tolerance. 330 $aRecent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21st century.  Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine.  Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate.  This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity.  Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future.  Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8985 606 $aRegenerative medicine 606 $aStem cells$xTherapeutic use 606 $aImmunogenetics 615 0$aRegenerative medicine. 615 0$aStem cells$xTherapeutic use. 615 0$aImmunogenetics. 676 $a616.02/774 676 $a616.02774 701 $aFairchild$b Paul J$01750118 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437824103321 996 $aThe immunological barriers to regenerative medicine$94184672 997 $aUNINA