LEADER 02911oam 2200469 450 001 9910437815203321 005 20190911112725.0 010 $a3-319-00708-4 024 7 $a10.1007/978-3-319-00708-3 035 $a(OCoLC)854563057 035 $a(MiFhGG)GVRL6YPL 035 $a(EXLCZ)992670000000406820 100 $a20130515d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aTowards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers /$fJanet T.F. Lau 205 $a1st ed. 2013. 210 1$aCham [Switzerland] :$cSpringer,$d2013. 215 $a1 online resource (xxii, 180 pages) $cillustrations (some color) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $a"ISSN: 2190-5053." 311 $a3-319-03316-6 311 $a3-319-00707-6 320 $aIncludes bibliographical references and index. 327 $aA Zinc(II) Phthalocyanine Conjugated with an Oxaliplatin Derivative for Dual Chemo- and Photodynamic Therapy -- Zinc(II) Phthalocyanine-Polyamine Conjugates as Efficient Photosensitizers for Photodynamic Therapy -- A Redox-Responsive Silicon(IV) Phthalocyanine for Targeted Photodynamic Therapy -- A Dual pH- and Redox-Responsive Phthalocyanine-Based Photosensitizer for Targeted Photodynamic Therapy. 330 $aJanet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, parts of the results have been published in prestigious scientific journals. 410 0$aSpringer theses. 606 $aPhotosensitizing compounds 606 $aCancer$xPhotochemotherapy 615 0$aPhotosensitizing compounds. 615 0$aCancer$xPhotochemotherapy. 676 $a541 700 $aLau$b Janet T F$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060870 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910437815203321 996 $aTowards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers$92515995 997 $aUNINA