LEADER 04195nam 22006615 450 001 9910437810203321 005 20200701011446.0 010 $a3-642-38962-7 024 7 $a10.1007/978-3-642-38962-7 035 $a(CKB)3420000000001559 035 $a(SSID)ssj0000960642 035 $a(PQKBManifestationID)11519342 035 $a(PQKBTitleCode)TC0000960642 035 $a(PQKBWorkID)10968310 035 $a(PQKB)11349504 035 $a(DE-He213)978-3-642-38962-7 035 $a(MiAaPQ)EBC3107006 035 $a(PPN)172427487 035 $a(EXLCZ)993420000000001559 100 $a20130729d2013 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aDynamics in Enzyme Catalysis /$fedited by Judith Klinman, Sharon Hammes- Schiffer 205 $a1st ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (IX, 212 p.) 225 1 $aTopics in Current Chemistry,$x0340-1022 ;$v337 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-642-38961-9 320 $aIncludes bibliographical references and index. 327 $aRelationship of Femtosecond?Picosecond Dynamics to Enzyme-Catalyzed H-Transfer -- Protein Conformational Disorder and Enzyme Catalysis -- A Surprising Role for Conformational Entropy in Protein Function -- Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations -- Structured Crowding and Its Effects on Enzyme Catalysis -- Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations -- Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase -- Protein Dynamics and the Enzymatic Reaction Coordinate. 330 $aChristopher M. Cheatum and Amnon Kohen Relationship of Femtosecond?Picosecond Dynamics to Enzyme-Catalyzed H-Transfer Cindy Schulenburg and Donald Hilvert Protein Conformational Disorder and Enzyme Catalysis A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole A Surprising Role for Conformational Entropy in Protein Function Travis P. Schrank, James O. Wrabl and Vincent J. Hilser Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations Buyong Ma and Ruth Nussinov Structured Crowding and Its Effects on Enzyme Catalysis Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations Karunesh Arora and Charles L. Brooks III Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase Steven D. Schwartz Protein Dynamics and the Enzymatic Reaction Coordinate. 410 0$aTopics in Current Chemistry,$x0340-1022 ;$v337 606 $aCatalysis 606 $aProteins  606 $aChemistry, Physical and theoretical 606 $aCatalysis$3https://scigraph.springernature.com/ontologies/product-market-codes/C29000 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aTheoretical and Computational Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C25007 615 0$aCatalysis. 615 0$aProteins . 615 0$aChemistry, Physical and theoretical. 615 14$aCatalysis. 615 24$aProtein Science. 615 24$aTheoretical and Computational Chemistry. 676 $a572/.4 702 $aKlinman$b Judith$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHammes- Schiffer$b Sharon$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437810203321 996 $aDynamics in Enzyme Catalysis$92504179 997 $aUNINA