LEADER 06183nam 2200685Ia 450 001 9910437809703321 005 20200520144314.0 010 $a1-299-40773-0 010 $a94-007-5179-6 024 7 $a10.1007/978-94-007-5179-8 035 $a(CKB)2670000000338245 035 $a(EBL)1030748 035 $a(OCoLC)828794447 035 $a(SSID)ssj0000878569 035 $a(PQKBManifestationID)11436030 035 $a(PQKBTitleCode)TC0000878569 035 $a(PQKBWorkID)10836846 035 $a(PQKB)11717145 035 $a(DE-He213)978-94-007-5179-8 035 $a(MiAaPQ)EBC1030748 035 $a(PPN)168340178 035 $a(EXLCZ)992670000000338245 100 $a20130315d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCadmium $efrom toxicity to essentiality /$fAstrid Sigel, Helmut Sigel, Roland K. O. Sigel, editors 205 $a1st ed. 2013. 210 $aDordrecht ;$aNew York $cSpringer$dc2013 215 $a1 online resource (587 p.) 225 1 $aMetal ions in life sciences ;$vvol. 11 300 $aDescription based upon print version of record. 311 $a94-017-8081-1 311 $a94-007-5178-8 320 $aIncludes bibliographical references and index. 327 $aCadmium: From Toxicity to Essentiality; Historical Development and Perspectives of the Series: Metal Ions in Life Sciences*; Metal Ions in Life Sciences; Preface to Volume 11; Cadmium: From Toxicity to Essentiality; Contents; Contributors to Volume 11; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; Chapter 1: The Bioinorganic Chemistry of Cadmium in the Context of Its Toxicity; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction; 1 Introduction 327 $a1 Introduction: Importance of Cadmium Accumulation in Plants1 Introduction; 1 Introduction; 1 Introduction; 2 Cadmium Coordination Chemistry of Biological Relevance; 2.1 Cadmium Complexes, Stabilities, and Properties; 2 Geochemistry of Cadmium; 2.1 Chemical Properties; 2 Biomarkers of Exposure; 2.1 Overview; 2 Cadmium Toxicity in Cells; 3 Detection of Intracellular Cadmium; 2 General Considerations and Basic Principles; 3 113Cd NMR Chemical Shifts from 113Cd-Substituted Metalloproteins; 2.1 Adenine; 2.2 N-Substituted Purines with Non-coordinating Pendant Arms 327 $a2 Complexes of Amino Acids and Derivatives2.1 General Characteristics of Cadmium(II) Complexes of Amino Acids; 1.1 Cadmium Accumulation in Indicator and Excluder Plants; 1.2 Active Cadmium Hyperaccumulation; 2 Sources and Exposures; 2.1 Occupational Sources and Exposures; 2 Epidemiology and Animal Carcinogenicity; 2.1 Carcinogenicity in Humans; 2 Cadmium Distribution in the Ocean; 2.1 Vertical Profiles; 2.2 Cadmium Protein Complexes; 2.2 Abundance in the Continental Crust; 2.2 Pre-analytic Phase; 3.1 Overview of Cadmium Detection 327 $a4 Specific Highlights of Studies on Alkaline Phosphatase, Calcium Binding Proteins, and Metallothioneins2.3 N-Substituted Purines with Potential Chelating Pendant Arms; 2.2 Complexes of Amino Acids with Non-coordinating Side Chains; 2 Ecological Role of Cadmium Hyperaccumulation; 2.2 Non-Occupational Sources and Exposures; 2.2 Carcinogenicity in Experimental Animals; 2.2 Isotope Composition; 2.3 Cadmium Interactions with Other Biomolecules; 3 Cadmium Biochemistry; 3 Mobilization of Cadmium; 3.1 Natural Sources; 2.3 Analytical Methods for the Determination of Cadmium 327 $a2.3.1 Inductively Coupled Plasma Mass Spectrometry3.2 Principles of the Development of Fluorescence Probes for Metal Ions; 3.3 Fluorescence Imaging of Cadmium with Calcium or Zinc Fluorescence Probes; 4.1 113Cd NMR and Alkaline Phosphatase; 4.2 113Cd NMR and Calcium Binding Proteins; 2.4 6-Mercaptopurine; 2.5 Oxopurines; 2.3 Complexes of Amino Acids with Coordinating Side Chains; 2.3.1 Complexes of Amino Acids with O-Donor Side Chains; 3 Mechanisms of Cadmium Hyperaccumulation; 3.1 Compartmentation of Cadmium in Tissues, Cells, and Organelles; 3 Entry Pathways, Transport, and Trafficking 327 $a3.1 Entry Pathways 330 $aCadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems. 410 0$aMetal ions in life sciences ;$vvol. 11. 606 $aCadmium 606 $aCadmium$xMetallurgy 615 0$aCadmium. 615 0$aCadmium$xMetallurgy. 676 $a571.954662 701 $aSigel$b Astrid$091114 701 $aSigel$b Helmut$091115 701 $aSigel$b Roland K. O$01750354 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437809703321 996 $aCadmium$94184980 997 $aUNINA