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024 7 $a10.1007/978-4-431-54231-5
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035   $a(EBL)1106269
035   $a(OCoLC)827212112
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035   $a(PQKBTitleCode)TC0000878733
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035   $a(DE-He213)978-4-431-54231-5
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100   $a20130125d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aDevelopment of Novel Hydrogen-Bond Donor Catalysts /$fby Tsubasa Inokuma
205   $a1st ed. 2013.
210  1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2013.
215   $a1 online resource (118 p.)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a4-431-54745-2 
311   $a4-431-54230-2 
320   $aIncludes bibliographical references.
327   $aIntroduction -- Development of HB donor catalysts -- Development and properties of novel HB donor catalysts -- Asymmetric Michael addition to alpha,beta-unsaturated imides catalyzed by HB donors -- Asymmetric Hydrazination of activated methylene compounds catalyzed by HB donors -- Development of hydroxy thiourea catalysts -- Asymmetric Michael addition of gamma-hydroxyenones and alkenylboronic acids -- Asymmetric Petasis Reaction of N-aryl-alpha-iminoamides and Alkenylboronates -- Conclusion.
330   $aThis work describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods. They were found to be effective for a variety of asymmetric transformations including Michael reactions of a, b-unsaturated imides and hydrazination reactions of 1,3-dicarbonyl compounds. Thiourea catalysts that have an additional functional group are also described. Specifically, thioureas that bear a hydroxyl group were synthesized and subsequently used as novel bifunctional organocatalysts for catalytic, asymmetric Petasis-type reactions involving organoboronic acids as nucleophiles. These addition reactions were difficult to achieve using existing organocatalysts. One of the developed catalytic methods can be applied to the synthesis of biologically interesting peptide-derived compounds possessing unnatural vinyl glycine moieties. These findings introduce new criteria required for the development of organocatalysts for asymmetric reactions, thus making a significant contribution to the field of organocatalysis.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aOrganic chemistry
606   $aMedicinal chemistry
606   $aCatalysis
606   $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
606   $aCatalysis$3https://scigraph.springernature.com/ontologies/product-market-codes/C29000
615  0$aOrganic chemistry.
615  0$aMedicinal chemistry.
615  0$aCatalysis.
615 14$aOrganic Chemistry.
615 24$aMedicinal Chemistry.
615 24$aCatalysis.
676   $a547.215
700   $aInokuma$b Tsubasa$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060621
906   $aBOOK
912   $a9910437807603321
996   $aDevelopment of Novel Hydrogen-Bond Donor Catalysts$92514657
997   $aUNINA