LEADER 02856nam 2200493Ia 450 001 9910437800803321 005 20200520144314.0 010 $a3-319-01134-0 024 7 $a10.1007/978-3-319-01134-9 035 $a(OCoLC)857660820 035 $a(MiFhGG)GVRL6WTX 035 $a(CKB)3710000000015818 035 $a(MiAaPQ)EBC1398636 035 $a(EXLCZ)993710000000015818 100 $a20130823d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aOrganotrifluoroborate preparation, coupling and hydrolysis /$fAlastair J. J. Lennox 205 $a1st ed. 2013. 210 $aCham ;$aNew York $cSpringer$dc2013 215 $a1 online resource (xv, 223 pages) $cillustrations (some color) 225 0 $aSpringer theses 300 $a"Doctoral thesis accepted by the University of Bristol, UK." 311 $a3-319-01133-2 320 $aIncludes bibliographical references. 327 $aGeneral Introduction -- Organotrifluoroborate Preparation -- Organotrifluoroborate Coupling -- Organotrifluoroborate Hydrolysis -- Conclusions and Future Work -- Experimental: General Experimental Details -- Experimental: Organotrifluoroborate Preparation -- Experimental: Organotrifluoroborate Coupling -- Experimental: Organotrifluoroborate Hydrolysis. 330 $aAlistair Lennox's thesis reports on the reactivity of organotrifluoroborates, which are becoming increasingly important reagents in synthesis. The thesis is divided into three sections. The first section describes a method for preparing organotrifluoroborates. The second section reports on a mechanistic investigation into the main application of RBF3K reagents as coupling partners in Suzuki-Miyaura coupling, phenomena identified as arising from organotrifluoroborate hydrolysis and fluoride release. The final section reports on a detailed investigation into the hydrolysis mechanism, a prerequisite for their Suzuki-Miyaura coupling, and how it may be predicted and controlled. This research has uncovered many interesting and useful details and shows how problems associated with Suzuki-Miyaura coupling can best be addressed. There has already been wide industrial uptake of the new procedures and insights. The broad nature and clear and succinct style will make the thesis a valuable resource for anyone working in synthesis, organometallic chemistry, or in homogeneous catalysis. 410 0$aSpringer theses. 606 $aSalts 606 $aHydrolysis 615 0$aSalts. 615 0$aHydrolysis. 676 $a541.395 700 $aLennox$b Alastair J. J$01064962 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437800803321 996 $aOrganotrifluoroborate Preparation, Coupling and Hydrolysis$92541931 997 $aUNINA