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010   $a9786613944122
010   $a3-642-32051-1
024 7 $a10.1007/978-3-642-32051-4
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035   $a(EBL)1030350
035   $a(OCoLC)809794112
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035   $a(PQKBTitleCode)TC0000738579
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035   $a(DE-He213)978-3-642-32051-4
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100   $a20120922h20122013  uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aNovel synthetic chemistry of ureas and amides $edoctoral thesis accepted by the University of Bristol, UK /$fMarc Hutchby
205   $a1st ed. 2013.
210   $aHeidelberg $cSpringer$d2012, c2013
215   $a1 online resource (178 p.)
225 1 $aSpringer theses : recognizing outstanding Ph.D. research,$x2190-5053
300   $aDescription based upon print version of record.
311   $a3-642-44890-9 
311   $a3-642-32050-3 
320   $aIncludes bibliographical references.
327   $aTransition metal catalysis -- Palladium catalysis -- Pd(II) catalysed aminocarbonylation of alkenes -- Carbonylation of aryl ureas -- Urea Hydrolysis -- Amide hydrolysis.
330   $aIn this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.
410  0$aSpringer theses.
606   $aOrganic compounds$xSynthesis
606   $aChemical bonds
606   $aUrea
606   $aAmides
615  0$aOrganic compounds$xSynthesis.
615  0$aChemical bonds.
615  0$aUrea.
615  0$aAmides.
676   $a660.6
700   $aHutchby$b Marc$01059105
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437798103321
996   $aNovel Synthetic Chemistry of Ureas and Amides$92504168
997   $aUNINA