LEADER 06885nam 22008535 450 001 9910437797603321 005 20250609112038.0 010 $a94-007-5561-9 024 7 $a10.1007/978-94-007-5561-1 035 $a(CKB)2670000000356487 035 $a(EBL)1083589 035 $a(OCoLC)841263185 035 $a(SSID)ssj0000880156 035 $a(PQKBManifestationID)11956618 035 $a(PQKBTitleCode)TC0000880156 035 $a(PQKBWorkID)10873302 035 $a(PQKB)11563164 035 $a(DE-He213)978-94-007-5561-1 035 $a(MiAaPQ)EBC1083589 035 $a(PPN)169141829 035 $a(MiAaPQ)EBC4072227 035 $a(EXLCZ)992670000000356487 100 $a20130418d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMetallomics and the Cell /$fedited by Lucia Banci 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (641 p.) 225 1 $aMetal Ions in Life Sciences,$x1559-0836 ;$v12 300 $aDescription based upon print version of record. 311 08$a94-007-9641-2 311 08$a94-007-5560-0 320 $aIncludes bibliographical references and index. 327 $aDedication to Ivano Bertini; Historical Development and Perspectives of the Series: Metal Ions in Life Sciences*; Metal Ions in Life Sciences.; Preface to Volume 12; Metallomics and the Cell; Contents; Contributors to Volume 12; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; Chapter 1: Metallomics and the Cell: Some Definitions and General Comments; 1 Introduction; 2 The "Omics" Perspective; 3 The "Cellular" Perspective; 4 Towards Systems Biology; 5 Concluding Remarks; Abbreviations; References 327 $aChapter 2: Technologies for Detecting Metals in Single Cells1 Introduction and Scope; 1.1 General Issues for Metal Detection; 1.2 Importance of Single Cell and Spatially Resolved Measurement; 1.3 Sample Preparation; 2 Mass Spectrometry; 2.1 Secondary Ion Mass Spectrometry; 2.2 Laser Ablation Mass Spectrometry; 2.3 Related Methods; 2.4 Examples; 3 Visible Light; 3.1 Design Considerations for Metal-Specific Fluorophores; 3.1.1 Metal-Binding Equilibria; 3.1.2 Other Considerations; 3.1.3 Exogenous Fluorophores; 3.1.4 Endogenous Fluorophores; 3.2 Two-Photon Excitation; 3.3 Examples 327 $a4 Intrinsic X-Ray Fluorescence4.1 Particle Excitation; 4.2 X-ray Excitation; 4.3 Examples; 4.3.1 Metal Speciation; 5 Concluding Remarks and Future Directions; Abbreviations and Definitions; References; Chapter 3: Sodium/Potassium Homeostasis in the Cell; 1 Introduction; 2 Sodium and Potassium as Enzymatic Cofactors; 2.1 Ionic Properties; 2.2 Sodium- and Potassium-Dependent Enzymes; 3 The Membrane Potential; 3.1 The Action Potential; 4 Na + and K + Gradients and Secondary Transporters; 4.1 Uptake of Amino Acids, Sugars, and Transmitters; 4.2 Co-transporters in Cell Volume and Ion Balances 327 $a4.2.1 Cell Volume4.2.2 Inhibitory or Excitatory Action of g -Aminobutyric Acid; 4.2.3 Re-uptake of Inorganic Solutes; 5 Homeostasis of the Na + and K + Gradients by the Na +,K + -ATPase; 5.1 The Subunits of the Na +,K + -ATPase; 5.2 The Structure of the Na +,K + -ATPase; 5.3 The Mechanism of the Na +,K + -ATPase; 5.4 Regulation of the Na +,K + -ATPase; 5.4.1 Posttranslational Modifications; 5.4.2 Cellular Interactions; 5.5 Na +,K + -ATPase Toxins; 5.5.1 Cardiotonic Glycosides; 5.5.2 Palytoxin; 6 Pathophysiology of Na +,K + -ATPase Disturbance; 7 Concluding Remarks and Future Directions 327 $aAbbreviationsReferences; Chapter 4: Magnesium Homeostasis in Mammalian Cells; 1 Introduction; 2 Cellular Mg 2+ Distribution; 3 Mg 2+ Transport Mechanisms; 3.1 Channels; 3.1.1 TRPM Channels; 3.1.1.1 TRPM7:; 3.1.1.2 TRPM6:; 3.1.2 Claudins; 3.1.3 MagT1; 3.1.4 Mrs2; 3.1.5 MMgTs; 3.2 Exchangers; 3.2.1 Na + -Dependent Exchanger (Na + /Mg 2+ Exchanger); 3.2.2 Na + -Independent Exchanger; 3.2.3 Mg 2+ /H + Exchange; 3.3 Carriers; 3.3.1 SLC41 (Solute Carrier Family 41); 3.3.2 ACDP2; 3.3.3 NIPA; 3.3.4 Huntingtin; 3.4 Mg 2+ Transport in Purified Plasma Membrane Vesicles 327 $a4 Regulation of Mg 2+ Transport and Homeostasis 330 $aMetallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc. Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context. 410 0$aMetal Ions in Life Sciences,$x1559-0836 ;$v12 606 $aLife sciences 606 $aChemistry, Inorganic 606 $aHuman physiology 606 $aScience$xStudy and teaching 606 $aPharmacy 606 $aLife Sciences, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L00004 606 $aInorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C16008 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aScience Education$3https://scigraph.springernature.com/ontologies/product-market-codes/O27000 606 $aPharmacy$3https://scigraph.springernature.com/ontologies/product-market-codes/F00008 615 0$aLife sciences. 615 0$aChemistry, Inorganic. 615 0$aHuman physiology. 615 0$aScience$xStudy and teaching. 615 0$aPharmacy. 615 14$aLife Sciences, general. 615 24$aInorganic Chemistry. 615 24$aHuman Physiology. 615 24$aScience Education. 615 24$aPharmacy. 676 $a572.5 702 $aBanci$b Lucia$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437797603321 996 $aMetallomics and the Cell$92497018 997 $aUNINA