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100   $a20121026d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aIdentification of Ligand Binding Site and Protein-Protein Interaction Area /$fedited by Irena Roterman-Konieczna
205   $a1st ed. 2013.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013.
215   $a1 online resource (172 p.)
225 1 $aFocus on Structural Biology,$x1571-4853 ;$v8
300   $aDescription based upon print version of record.
311   $a94-017-8284-9 
311   $a94-007-5284-9 
320   $aIncludes bibliographical references and index.
327   $aContributors -- Foreword -- Chapter 1 SuMo, J-A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage -- Chapter 2 Identification of pockets on protein surface to predict protein?ligand binding sites, Binding Huang -- Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman -- Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roterman -- Chapter 5 Docking predictions of protein-protein interactions and their assessment, Joel Janin -- Chapter 6 Prediction of protein-protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman -- Chapter 7 Support for Cooperative Experiments in e-Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara-Masis, Z. Zhao, M. Bubak -- Index.
330   $aThis volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task ? it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
410  0$aFocus on Structural Biology,$x1571-4853 ;$v8
606   $aMedicine
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
615  0$aMedicine.
615 14$aBiomedicine, general.
676   $a572.33
702   $aRoterman-Konieczna$b Irena$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910437796703321
996   $aIdentification of Ligand Binding Site and Protein-Protein Interaction Area$92504166
997   $aUNINA