LEADER 03576nam 2200589 a 450 001 9910437796703321 005 20200520144314.0 010 $a94-007-5285-7 024 7 $a10.1007/978-94-007-5285-6 035 $a(CKB)2670000000280493 035 $a(EBL)1030738 035 $a(OCoLC)819631493 035 $a(SSID)ssj0000798779 035 $a(PQKBManifestationID)11501268 035 $a(PQKBTitleCode)TC0000798779 035 $a(PQKBWorkID)10743606 035 $a(PQKB)11273872 035 $a(DE-He213)978-94-007-5285-6 035 $a(MiAaPQ)EBC1030738 035 $a(PPN)168340461 035 $a(EXLCZ)992670000000280493 100 $a20121009d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIdentification of ligand binding site and protein-protein interaction area /$fIrena Roterman-Konieczna, editor 205 $a1st ed. 2013. 210 $aDordrecht $cSpringer$d2013 215 $a1 online resource (172 p.) 225 0$aFocus on structural biology,$x1571-4853 ;$vv. 8 300 $aDescription based upon print version of record. 311 $a94-017-8284-9 311 $a94-007-5284-9 320 $aIncludes bibliographical references and index. 327 $aContributors -- Foreword -- Chapter 1 SuMo, J-A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage -- Chapter 2 Identification of pockets on protein surface to predict protein?ligand binding sites, Binding Huang -- Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman -- Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roterman -- Chapter 5 Docking predictions of protein-protein interactions and their assessment, Joel Janin -- Chapter 6 Prediction of protein-protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman -- Chapter 7 Support for Cooperative Experiments in e-Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara-Masis, Z. Zhao, M. Bubak -- Index. 330 $aThis volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task ? it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research. 410 0$aFocus on Structural Biology,$x1571-4853 ;$v8 606 $aLigand binding (Biochemistry) 606 $aProtein binding 615 0$aLigand binding (Biochemistry) 615 0$aProtein binding. 676 $a572.33 701 $aRoterman-Konieczna$b Irena$01133571 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437796703321 996 $aIdentification of ligand binding site and protein-protein interaction area$94184777 997 $aUNINA