LEADER 03516nam 2200577Ia 450 001 9910437624603321 005 20200520144314.0 010 $a1-299-40783-8 010 $a94-007-5787-5 024 7 $a10.1007/978-94-007-5787-5 035 $a(CKB)2550000001018204 035 $a(EBL)1083647 035 $a(OCoLC)832728869 035 $a(SSID)ssj0000879436 035 $a(PQKBManifestationID)11442839 035 $a(PQKBTitleCode)TC0000879436 035 $a(PQKBWorkID)10851562 035 $a(PQKB)10298368 035 $a(DE-He213)978-94-007-5787-5 035 $a(MiAaPQ)EBC1083647 035 $a(PPN)169141918 035 $a(EXLCZ)992550000001018204 100 $a20130327d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOxidative stress and redox regulation /$fUrsula Jakob, Dana Reichmann, editors 205 $a1st ed. 2013. 210 $aDordrecht ;$aNew York $cSpringer$dc2013 215 $a1 online resource (488 p.) 300 $aIncludes index. 311 $a94-007-9444-4 311 $a94-007-5786-7 327 $aChapter 1 The Chemistry of Thiol Oxidation and Detection -- Chapter 2 Radical Scavenging by Thiols and the Fate of Thiyl Radicals -- Chapter 3 Redox Homeostasis -- Chapter 4 Sulfenic Acids and Peroxiredoxins in Oxidant Defense and Signaling -- Chapter 5  Fluorescent imaging of redox species in multicellular organisms -- Chapter 6 Redox Proteomics -- Chapter 7 Computational redox biology: methods and applications -- Chapter 8  Redox regulation in plants: Glutathione and ?Redoxin? related families -- Chapter 9  Prokaryotic Redox Switches -- Chapter 10   Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies -- Chapter 11 Reactive Oxygen Species, Kinase Signaling, and Redox Regulation of Epigenetics -- Chapter 12 Redox regulation of stem cell function -- Chapter 13 Oxidative Stress in Infectious Diseases -- Chapter 14 Oxidative Stress in Aging -- Chapter 15 Oxidative Stress in Cancer -- Chapter 16 Redox Pathways as a Platform in Drug Development. 330 $aMany physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease. 606 $aOxidative stress 606 $aPost-translational modification 615 0$aOxidative stress. 615 0$aPost-translational modification. 676 $a616.07 701 $aJakob$b Ursula$01758501 701 $aReichmann$b Dana$01758502 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437624603321 996 $aOxidative stress and redox regulation$94196728 997 $aUNINA