LEADER 04989nam 22006135 450 001 9910437624303321 005 20200706235808.0 010 $a3-7091-0885-3 024 7 $a10.1007/978-3-7091-0885-7 035 $a(CKB)2550000001199613 035 $a(EBL)1697793 035 $a(OCoLC)881165917 035 $a(SSID)ssj0001178942 035 $a(PQKBManifestationID)11667684 035 $a(PQKBTitleCode)TC0001178942 035 $a(PQKBWorkID)11169378 035 $a(PQKB)10325415 035 $a(DE-He213)978-3-7091-0885-7 035 $a(MiAaPQ)EBC1697793 035 $a(PPN)176124896 035 $a(EXLCZ)992550000001199613 100 $a20140121d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProteases: Structure and Function /$fedited by Klaudia Brix, Walter Stöcker 205 $a1st ed. 2013. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2013. 215 $a1 online resource (568 p.) 300 $aDescription based upon print version of record. 311 $a3-7091-0884-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1 Protease families, evolution and mechanisms of action "Set the stage" -- 1.1 Enzyme families, prototypes and catalytic mechanisms --  1.2 Enzyme kinetics, mathematical modelling and perspectives --  1.3 Structure determination and search for inhibitors -- 2 Regulation of proteolysis "Positioning and teaming-up to control activity" -- 2.1 Compartmentalization of proteolysis -- 2.2 Biosynthesis of lysosomal proteases -- 2.3 Interactions of proteases and inhibitors / networking in the degradome -- 2.4 In vivo analysis of the protease and inhibitors concert -- 3 Proteases in development "Born to be right" -- 3.1 Proteases for pattern formation during morphogenesis -- 3.2 Proteases in death pathways (apoptosis, necrosis) -- 4 Proteases in physiology and pathophysiology ?Cleave to function in health or to cause disease" -- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling) -- 4.2 Proteases in control of physiology -- 4.3 Cancer: invasion and metastasis -- 4.4 Bacterial proteases -- 4.5 Viral proteases. 330 $aProteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death ? from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead. 606 $aEnzymology 606 $aProteins 606 $aEnzymology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14070 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 615 0$aEnzymology. 615 0$aProteins. 615 14$aEnzymology. 615 24$aProtein Structure. 615 24$aProtein Science. 676 $a572 676 $a572.76 702 $aBrix$b Klaudia$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aStöcker$b Walter$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437624303321 996 $aProteases: Structure and Function$92530769 997 $aUNINA