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010   $a3-0348-0688-4
024 7 $a10.1007/978-3-0348-0688-6
035   $a(CKB)2670000000533705
035   $a(EBL)1398546
035   $a(OCoLC)858763846
035   $a(SSID)ssj0000986606
035   $a(PQKBManifestationID)11544770
035   $a(PQKBTitleCode)TC0000986606
035   $a(PQKBWorkID)10938782
035   $a(PQKB)10960147
035   $a(DE-He213)978-3-0348-0688-6
035   $a(MiAaPQ)EBC1398546
035   $a(PPN)172421942
035   $a(EXLCZ)992670000000533705
100   $a20130604d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGenomics of pattern recognition receptors $eapplications in oncology and cardiovascular diseases /$fAnton G. Kutikhin, Arseniy E. Yuzhalin
205   $a1st ed. 2013.
210   $aNew York $cSpringer$d2013
215   $a1 online resource (190 p.)
300   $aDescription based upon print version of record.
311   $a3-0348-0687-6 
311   $a3-0348-0794-5 
320   $aIncludes bibliographical references.
327   $aThe Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
330   $aThis book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
606   $aCell receptors
606   $aGenetics
606   $aReceptors
606   $aImmunology
606   $aCancer$xResearch
606   $aHuman genetics
615  0$aCell receptors.
615  0$aGenetics.
615  0$aReceptors.
615  0$aImmunology.
615  0$aCancer$xResearch.
615  0$aHuman genetics.
676   $a570
676   $a572696
676   $a574.87
676   $a599935
700   $aKutikhin$b Anton G$01059920
701   $aYuzhalin$b Arseniy E$01751477
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437623603321
996   $aGenomics of pattern recognition receptors$94186464
997   $aUNINA