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010   $a3-0348-0688-4
024 7 $a10.1007/978-3-0348-0688-6
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035   $a(EBL)1398546
035   $a(OCoLC)858763846
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035   $a(PQKBTitleCode)TC0000986606
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035   $a(DE-He213)978-3-0348-0688-6
035   $a(MiAaPQ)EBC1398546
035   $a(PPN)172421942
035   $a(EXLCZ)992670000000533705
100   $a20130828d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGenomics of Pattern Recognition Receptors $eApplications in Oncology and Cardiovascular Diseases /$fby Anton G. Kutikhin, Arseniy E. Yuzhalin
205   $a1st ed. 2013.
210  1$aBasel :$cSpringer Basel :$cImprint: Springer,$d2013.
215   $a1 online resource (190 p.)
300   $aDescription based upon print version of record.
311   $a3-0348-0687-6 
311   $a3-0348-0794-5 
320   $aIncludes bibliographical references.
327   $aThe Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
330   $aThis book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
606   $aProteins 
606   $aImmunology
606   $aCancer research
606   $aHuman genetics
606   $aOncology  
606   $aCardiology
606   $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037
615  0$aProteins .
615  0$aImmunology.
615  0$aCancer research.
615  0$aHuman genetics.
615  0$aOncology  .
615  0$aCardiology.
615 14$aReceptors.
615 24$aImmunology.
615 24$aCancer Research.
615 24$aHuman Genetics.
615 24$aOncology.
615 24$aCardiology.
676   $a570
676   $a572696
676   $a574.87
676   $a599935
700   $aKutikhin$b Anton G$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059920
702   $aYuzhalin$b Arseniy E$4aut$4http://id.loc.gov/vocabulary/relators/aut
906   $aBOOK
912   $a9910437623603321
996   $aGenomics of Pattern Recognition Receptors$92509574
997   $aUNINA