LEADER 03010nam 2200577Ia 450 001 9910437621803321 005 20200520144314.0 010 $a1-4614-4660-0 010 $a1-299-19720-5 024 7 $a10.1007/978-1-4614-4660-6 035 $a(CKB)2670000000529989 035 $a(EBL)1081850 035 $a(OCoLC)826853733 035 $a(SSID)ssj0000878962 035 $a(PQKBManifestationID)11560822 035 $a(PQKBTitleCode)TC0000878962 035 $a(PQKBWorkID)10850323 035 $a(PQKB)11009698 035 $a(DE-He213)978-1-4614-4660-6 035 $a(MiAaPQ)EBC1081850 035 $a(PPN)168300850 035 $a(EXLCZ)992670000000529989 100 $a20130116d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenetic and molecular epidemiology of multiple myeloma /$fSuzanne Lentzsch, editor 205 $a1st ed. 2013. 210 $aNew York, NY $cSpringer$dc2013 215 $a1 online resource (130 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-4659-7 311 $a1-4899-9865-9 320 $aIncludes bibliographical references and index. 327 $aPreface -- Genetics of Multiple Myeloma -- Gene expression signature in MGUS and multiple myeloma -- Cap-Dependent Protein Translation Initiation in Multiple Myeloma: an Attractive Target for Therapy -- IRES-dependent, CAP-independent translation in Multiple Myeloma -- Epigenetic gene silencing as a new target for multiple myeloma -- Role of Bone Disease in the Pathogenesis of Multiple Myeloma -- Index. 330 $aThis state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.  Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists. 606 $aMultiple myeloma$xEpidemiology 606 $aB cells$xTumors 615 0$aMultiple myeloma$xEpidemiology. 615 0$aB cells$xTumors. 676 $a616.99418 701 $aLentzsch$b Suzanne$01755170 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437621803321 996 $aGenetic and molecular epidemiology of multiple myeloma$94191859 997 $aUNINA