LEADER 05381nam 22007935 450 001 9910437621003321 005 20200701055948.0 010 $a9786613936059 010 $a1-283-62360-9 010 $a1-4614-3991-4 024 7 $a10.1007/978-1-4614-3991-2 035 $a(CKB)2670000000533018 035 $a(EBL)994611 035 $a(OCoLC)811620806 035 $a(SSID)ssj0000766950 035 $a(PQKBManifestationID)11473404 035 $a(PQKBTitleCode)TC0000766950 035 $a(PQKBWorkID)10732521 035 $a(PQKB)10076952 035 $a(DE-He213)978-1-4614-3991-2 035 $a(MiAaPQ)EBC994611 035 $a(PPN)168298961 035 $a(EXLCZ)992670000000533018 100 $a20120919d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiophysical approaches to translational control of gene expression /$fedited by Jonathan D. Dinman 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (324 p.) 225 1 $aBiophysics for the Life Sciences ;$v1 300 $aDescription based upon print version of record. 311 $a1-4614-3990-6 311 $a1-4899-8709-6 320 $aIncludes bibliographical references and index. 327 $aX-ray analysis of prokaryotic and eukaryotic ribosomes -- A passage through the ribosome by Cryo-EM -- Molecular dynamics simulations of the ribosome -- Structural analyses of the ribosome by chemical modification methods -- Methods for studying the interactions of translation factors with the ribosome -- Riboproteomic approaches to understanding IRES elements -- Rapid kinetic analysis of protein synthesis -- Investigating RNAs Involved in Translational Control by NMR and SAXS -- Analyses of RNA-ligand interactions by fluorescence anisotropy -- Approaches for the Identification and Characterization of RNA-Protein Interactions -- A multidisciplinary approach to RNA Localization -- Virtual Screening for RNA-interacting Small Molecules -- The ?fifth? RNA nucleotide: a role for ribosomal RNA pseudouridylation in control of gene expression at the translational level -- Translational Control of Synaptic Plasticity and Memory. 330 $aWhen quantum mechanics was first proposed a century ago, nobody could have anticipated how deeply it would affect our lives.  Today, we are connected and powered through devices whose existence is predicated on the basic principles of this strange physics.  Not even the biological sciences have escaped its reach.  As scientists query the deepest mysteries of the living world, the physical scales probed and the types of questions asked are increasingly blurring the lines between biology and physics.  The hybrid field of biophysics represents the new frontier of the 21st century. The ribosome has been at the heart of three Nobel Prizes.  Understanding its essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis has been one of the central foundations in our understanding of the biology at the molecular level.  With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm. This book provides a premier resource to a wide audience, whether it be the general reader seeking a broad view of the field, a clinician interested in the role of protein translation in human disease, the bench researcher looking for state-of-the-art technologies, or computational scientists involved in cutting edge molecular modeling. 410 0$aBiophysics for the Life Sciences ;$v1 606 $aGene expression 606 $aBiophysics 606 $aBiological physics 606 $aBiochemistry 606 $aNucleic acids 606 $aCrystallography 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011 606 $aCrystallography and Scattering Methods$3https://scigraph.springernature.com/ontologies/product-market-codes/P25056 615 0$aGene expression. 615 0$aBiophysics. 615 0$aBiological physics. 615 0$aBiochemistry. 615 0$aNucleic acids. 615 0$aCrystallography. 615 14$aGene Expression. 615 24$aBiological and Medical Physics, Biophysics. 615 24$aBiochemistry, general. 615 24$aNucleic Acid Chemistry. 615 24$aCrystallography and Scattering Methods. 676 $a612.014 702 $aDinman$b Jonathan D$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437621003321 996 $aBiophysical approaches to translational control of gene expression$92513104 997 $aUNINA