LEADER 03086nam 2200541Ia 450 001 9910437620903321 005 20200520144314.0 010 $a94-007-4667-9 024 7 $a10.1007/978-94-007-4667-1 035 $a(CKB)2550000001047287 035 $a(EBL)1206400 035 $a(SSID)ssj0000880099 035 $a(PQKBManifestationID)11524670 035 $a(PQKBTitleCode)TC0000880099 035 $a(PQKBWorkID)10873235 035 $a(PQKB)11452900 035 $a(DE-He213)978-94-007-4667-1 035 $a(MiAaPQ)EBC1206400 035 $a(PPN)169141764 035 $a(EXLCZ)992550000001047287 100 $a20130129d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe chaperonopathies $ediseases with defective molecular chaperones /$fAlberto J.L. Macario, Everly Conway de Macario, Francesco Cappello 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (116 p.) 225 1 $aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 300 $aDescription based upon print version of record. 311 $a94-007-4666-0 327 $aOverview and book plan -- Chaperones: General characteristics and classifications -- The chaperonopathies: classification, mechanisms, structural features -- Structural and hereditary chaperonopathies: mutation -- Other genetic chaperonopathies -- Acquired chaperonopathies -- Other types of chaperonopathies -- Impact of chaperonopathies in protein homeostasis and beyond -- Extracellular chaperones. 330 $aMemory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer. 410 0$aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 606 $aMolecular chaperones 606 $aDiseases$xMolecular 615 0$aMolecular chaperones. 615 0$aDiseases$xMolecular. 676 $a572.633 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437620903321 996 $aThe Chaperonopathies$92513103 997 $aUNINA