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200 10$aCholesterol and presynaptic glutamate transport in the brain /$fTatiana Borisova
205   $a1st ed. 2013.
210   $aNew York $cSpringer$d2013
215   $a1 online resource (90 p.)
225 1 $aSpringerBriefs in neuroscience ;$v12
300   $aDescription based upon print version of record.
311   $a1-4614-7758-1 
320   $aIncludes bibliographical references.
327   $aPresynaptic glutamate transport in the brain -- Cholesterol and its role in synaptic transmission -- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals -- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals -- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals -- Neuroprotection by lowering cholesterol.
330   $aGlutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity.   In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits.
410  0$aSpringerBriefs in neuroscience.
606   $aNeurobiology
606   $aNeurotransmitters
606   $aCholesterol$xPhysiological effect
615  0$aNeurobiology.
615  0$aNeurotransmitters.
615  0$aCholesterol$xPhysiological effect.
676   $a612.8042
700   $aBorisova$b Tatiana$01059919
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906   $aBOOK
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996   $aCholesterol and Presynaptic Glutamate Transport in the Brain$92509572
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