LEADER 03005nam  2200577Ia 450 
001 9910437620103321
005 20200520144314.0
010   $a3-0348-0682-5
024 7 $a10.1007/978-3-0348-0682-4
035   $a(CKB)2670000000406494
035   $a(EBL)1398545
035   $a(SSID)ssj0000958047
035   $a(PQKBManifestationID)11485122
035   $a(PQKBTitleCode)TC0000958047
035   $a(PQKBWorkID)10986689
035   $a(PQKB)11749943
035   $a(DE-He213)978-3-0348-0682-4
035   $a(MiAaPQ)EBC1398545
035   $a(PPN)172421934
035   $a(EXLCZ)992670000000406494
100   $a20130731d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGamma-glutamyl transpeptidases $estructure and function /$fby Immacolata Castellano, Antonello Merlino
205   $a1st ed. 2013.
210   $aBasel $cSpringer$d2013
215   $a1 online resource (65 p.)
225  0$aSpringerBriefs in biochemistry and molecular biology
300   $aDescription based upon print version of record.
311   $a3-0348-0681-7 
320   $aIncludes bibliographical references.
327   $a 1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of ?-GTs -- 4 Autoprocessing and reaction mechanism of ?-GTs -- 5 ?-GT in bioclinical -- 6 ?-GTs: biotechnological and biomedical applications -- 7 Conclusions -- References.
330   $a Gamma-Glutamyl Transpeptidases (?-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the ?-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released ?-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). ?-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.?-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson?s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of ?-GTs and gives information about applications of ?-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
410  0$aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353
606   $aPeptidase
606   $aTranspeptidation
615  0$aPeptidase.
615  0$aTranspeptidation.
676   $a612.0151
700   $aCastellano$b Immacolata$01060386
701   $aMerlino$b Antonello$01762279
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437620103321
996   $aGamma-glutamyl transpeptidases$94202092
997   $aUNINA