LEADER 03932nam 2200589Ia 450 001 9910437618903321 005 20170814174505.0 010 $a1-283-61317-4 010 $a9786613925626 010 $a1-4614-2218-3 024 7 $a10.1007/978-1-4614-2218-1 035 $a(CKB)2670000000245978 035 $a(EBL)973608 035 $a(OCoLC)809542581 035 $a(SSID)ssj0000738489 035 $a(PQKBManifestationID)11434386 035 $a(PQKBTitleCode)TC0000738489 035 $a(PQKBWorkID)10791725 035 $a(PQKB)10620041 035 $a(DE-He213)978-1-4614-2218-1 035 $a(MiAaPQ)EBC973608 035 $a(PPN)168295962 035 $a(EXLCZ)992670000000245978 100 $a20120921h20122013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMyelin repair and neuroprotection in multiple sclerosis /$fIan D. Duncan, Robin J.M. Franklin, editors 210 $aNew York $cSpringer$d2012, c2013 215 $a1 online resource (295 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-2217-5 320 $aIncludes bibliographical references and index. 327 $aDevelopment of oligodendrocytes in the vertebrate CNS -- Demyelination and remyelination in multiple sclerosis -- Microglia function in MS pathology -- Endogenous remyelination in the CNS -- Exogenous cell myelin repair and neuroprotection in multiple sclerosis -- A peripheral alternative to central nervous system myelin repair -- Immune modulation and repair following neural stem transplantation -- Axonal protection with sodium channel blocking agents in models of multiple sclerosis -- Effects of current medical therapies on reparative and neuroprotective functions in multiple sclerosis -- Imaging of demyelination and remyelination in multiple sclerosis -- Designing clinical trials to test neuroprotective therapies in multiple sclerosis. 330 $aMyelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS).  A number of research frontiers still exist in this challenging disease.  The cause remains elusive, preventing breakthroughs in its prevention.  The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches.  However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources.  Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.   Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients. . 606 $aMyelin sheath 606 $aMultiple sclerosis$xPatients$xRehabilitation 615 0$aMyelin sheath. 615 0$aMultiple sclerosis$xPatients$xRehabilitation. 676 $a616.8 676 $a616.83407 701 $aDuncan$b Ian D$01065513 701 $aFranklin$b Robin J. M$01065514 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437618903321 996 $aMyelin repair and neuroprotection in multiple sclerosis$92546197 997 $aUNINA