LEADER 00840nam0-22003011i-450 001 990001770800403321 005 20190529131402.0 035 $a000177080 035 $aFED01000177080 035 $a(Aleph)000177080FED01 035 $a000177080 100 $a20030910d1968----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aEccezionali per colore e per profumo, i fiori di Plumeria$fEmanuele Flaccomio 210 $a[S.l.$cs.n.]$d1968 215 $a1 p.$d30 cm 610 0 $aPlumeria 676 $a635.9 700 1$aFlaccomio,$bEmanuele$073001 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aLG 912 $a990001770800403321 952 $a60 OP. 79/8$b41436$fFAGBC 959 $aFAGBC 996 $aEccezionali per colore e per profumo, i fiori di Plumeria$9363557 997 $aUNINA LEADER 03072nam 2200553Ia 450 001 9910437617803321 005 20200520144314.0 010 $a1-4614-7309-8 024 7 $a10.1007/978-1-4614-7309-1 035 $a(CKB)2670000000388020 035 $a(EBL)1317570 035 $a(SSID)ssj0000924373 035 $a(PQKBManifestationID)11499754 035 $a(PQKBTitleCode)TC0000924373 035 $a(PQKBWorkID)10870889 035 $a(PQKB)11309884 035 $a(DE-He213)978-1-4614-7309-1 035 $a(MiAaPQ)EBC1317570 035 $a(PPN)170488713 035 $a(EXLCZ)992670000000388020 100 $a20130708d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGenetic variants in Alzheimer's disease /$fKevin Morgan 205 $a1st ed. 2013. 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (256 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-9799-7 311 $a1-4614-7308-X 320 $aIncludes bibliographical references and indexes. 327 $aThe Genetics of Alzheimer?s disease: Introduction and Perspective for the Future -- Apolipoprotein E -- Clusterin -- PICALM -- Complement Component (3b/4b) Receptor 1(CR1) -- Bridging Integrator 1 (BIN1) -- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7) -- Membrane-spanning 4-domains subfamily A, MS4A cluster -- Sialic acid binding immunoglobulin-like lectin-3 (CD33) -- Erythropoietin-producing human hepatocellular carcinoma (EphA1) -- CD2-associated protein (CD2AP) -- Other Genes Implicated in Alzheimer?s Disease -- The Future Role of Biomarkers in Alzheimer?s Disease Diagnostics -- Index. 330 $aSince 2009, a revolution has been witnessed in Alzheimer?s Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer?s disease (LOAD) based on evidence of genetic association. These ?AD susceptibility genes? are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses. 606 $aAlzheimer's disease$xGenetic aspects 606 $aNeurogenetics 615 0$aAlzheimer's disease$xGenetic aspects. 615 0$aNeurogenetics. 676 $a616.831042 700 $aMorgan$b Kevin$0146919 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437617803321 996 $aGenetic variants in Alzheimer's disease$94187010 997 $aUNINA