LEADER 06015nam 2200673 a 450 001 9910437617403321 005 20200520144314.0 010 $a1-283-63389-2 010 $a9786613946348 010 $a94-007-4632-6 024 7 $a10.1007/978-94-007-4632-9 035 $a(CKB)2560000000091182 035 $a(EBL)994559 035 $a(OCoLC)809770931 035 $a(SSID)ssj0000741995 035 $a(PQKBManifestationID)11400770 035 $a(PQKBTitleCode)TC0000741995 035 $a(PQKBWorkID)10743848 035 $a(PQKB)11213245 035 $a(DE-He213)978-94-007-4632-9 035 $a(MiAaPQ)EBC994559 035 $a(PPN)168338564 035 $a(EXLCZ)992560000000091182 100 $a20120712d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTelomere territory and cancer /$fParvin Mehdipour, editor 205 $a1st ed. 2013. 210 $aDordrecht [Netherlands] ;$aNew York $cSpringer$d2013 215 $a1 online resource (212 p.) 300 $aDescription based upon print version of record. 311 $a94-007-9547-5 311 $a94-007-4631-8 320 $aIncludes bibliographical references and index. 327 $aPreface; Contents; Abbreviations and Acronyms; Contributors; Chapter-1; Telomerase: from Aging to Human Cancers; 1.1 Introduction; 1.2 Telomerase in Aging; 1.3 Telomerase in Leukemia; 1.4 Telomerase in Lymphomas; 1.5 Telomerase in Carcinomas; 1.6 Telomerase in Sarcomas; 1.7 Telomerase Targeted for Cancer Therapy; 1.8 Conclusions and Future Perspectives; References; Chapter-2; Telomerase: Basic and Clinical Approaches; 2.1 Introduction; 2.2 Telomerase Structure; 2.3 Telomerase Regulation; 2.3.1 Pretranslational Regulation; 2.3.2 Posttranscriptional Regulation; 2.3.3 Telomerase Activators 327 $a2.3.3.1 Akt kinase2.3.3.2 Protein kinase C and IP6; 2.3.4 Telomerase Repressors; 2.3.4.1 c-Abl; 2.3.4.2 PP2A; 2.4 Telomerase Activity and Expression of Its RNA Component (hTR) in Breast Cancer Patients (Adapted from Hosseini et al. 2006a Hosseini et al. 2006b); 2.4.1 Methods; 2.4.2 Results; 2.4.3 Discussion; 2.5 Expression of hTR and hTERT in Human Breast Cancer Patients: A Clinical Based Data (Adapted from Hosseini et al. 2006a Hosseini et al. 2006b); 2.5.1 Results; 2.5.2 Discussion; References; Chapter-3 327 $aDetection of Telomerase Activity: A New Strategy for Detecting Low Activity of Telomerase3.1 Introduction; 3.2 TRAP Assay; 3.3 TRAP-SPA; 3.4 Real-Time Quantitative Assay (RQ-TRAP); 3.5 ISTRAP; 3.6 PCR-Free Telomerase Detection; 3.7 TMA/HPA; 3.8 A New Strategy for Detecting Low Activity of Telomerase; 3.8.1 Material and Methods; 3.8.2 Results; 3.8.3 Discussion; References; Chapter-4; Telomere, Regulation and Tumorigenesis; 4.1 Introduction; 4.2 Telomeric DNA; 4.3 Telomeric Proteins and Its Regulation; 4.4 Telomeric Proteins and DNA Repair; 4.5 Telomeric Position Effect and Its Proteins 327 $a4.6 Telomere Protection and Maintenance4.7 Telomere Maintenance and DNA Damage Response; 4.8 Telomeres and Homologous Recombination; 4.9 Alternative Mechanism of Telomere Maintenance; 4.10 Telomere Function in Meiosis; 4.11 Telomere Dysfunction and Tumorigenesis; 4.12 Telomere and Telomerase in Brain Tumors; References; Chapter-5; Novel Hypothesis on Telomere Length: Heterogenic Targets as Genomic/Somatic Diverse Value in Breast Cancer and Brain Tumor; 5.1 Introduction; 5.1.1 Techniques to Measure TL At a Glance; 5.2 Cell; 5.2.1 Cell Is Core Spring of Our Life 327 $a5.2.2 The Initiative Reports on Tumor Evolution Contributed by5.2.3 Cells Live, Divide and Die; 5.3 Pedigree-Based Insight in Cancer; 5.3.1 The Characteristics and Impact of Pedigree-Based Research; 5.4 Diversity and Evolution; 5.4.1 Hypothesis and Tumorigenesis; 5.4.2 Questions on Some Facts in Cancer Biology; 5.4.3 Diversity; 5.5 Natural Selection; 5.6 Basic Facts About Telomere at a Glance; 5.7 Evolution and Novel Hypothesis on Telomere Length; 5.7.1 Modeling and Hypothesis; 5.7.2 Pedigree as a Core in Cancer Research; 5.7.2.1 Sample Designing; 5.7.2.2 Patients and Control Groups 327 $a5.7.2.3 Brief Strategy for Materials and Methods 330 $aTiming, racing, combating, struggling and targeting is some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ?telomeres are messengers of NATURE?, let?s to know them as they are. 606 $aTelomere 606 $aTelomerase 606 $aCancer cells 615 0$aTelomere. 615 0$aTelomerase. 615 0$aCancer cells. 676 $a572.87 701 $aMehdipour$b Parvin$01757365 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437617403321 996 $aTelomere territory and cancer$94195211 997 $aUNINA