LEADER 03986nam 2200601Ia 450 001 9910437615603321 005 20200520144314.0 010 $a1-4614-7969-X 024 7 $a10.1007/978-1-4614-7969-7 035 $a(CKB)2670000000530517 035 $a(EBL)1398496 035 $a(OCoLC)858763758 035 $a(SSID)ssj0000986623 035 $a(PQKBManifestationID)11942278 035 $a(PQKBTitleCode)TC0000986623 035 $a(PQKBWorkID)10938068 035 $a(PQKB)11602195 035 $a(DE-He213)978-1-4614-7969-7 035 $a(MiAaPQ)EBC1398496 035 $a(PPN)172420342 035 $a(EXLCZ)992670000000530517 100 $a20060217d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStearoyl-CoA Desaturase genes in lipid metabolism /$fJames M. Ntambi, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (241 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-7968-1 311 $a1-4939-0153-2 320 $aIncludes bibliographical references and index. 327 $aSCD genes of fatty acid synthesis -- SCD genes in heart metabolism -- SCD genes in liver metabolism -- SCD genes in harderian and perpetual glands -- SCD genes In lipogenesis -- SCD genes lipoproteins -- SCD genes in WAT -- SCD genes in muscle -- SCD genes in the brain -- SCD genes in inflammation -- SCD genes in ER Stress -- SCD genes in skin -- SCD genes in insulin signaling -- SCD genes in thermogenesis -- SCD genes in diabetes -- SCD genes atherosclerosis -- SCD genes in Adipocyte differentiation -- SCD genes and epigenetics -- SCD genes in fatty liver disease -- SCD genes in Colitis -- SCD genes in leptin signaling. 330 $aJames Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date. 606 $aCoenzymes 606 $aLipids$xMetabolism 615 0$aCoenzymes. 615 0$aLipids$xMetabolism. 676 $a572.57 676 $a599935 676 $a610 676 $a611.01816 701 $aNtambi$b James M$01763277 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437615603321 996 $aStearoyl-CoA Desaturase genes in lipid metabolism$94203636 997 $aUNINA