LEADER 05940nam 2200745Ia 450 001 9910437615503321 005 20200520144314.0 010 $a9786613923936 010 $a9781283611480 010 $a1283611481 010 $a9789400747197 010 $a9400747195 024 7 $a10.1007/978-94-007-4719-7 035 $a(CKB)2560000000091190 035 $a(EBL)971833 035 $a(OCoLC)809767433 035 $a(SSID)ssj0000716765 035 $a(PQKBManifestationID)11477561 035 $a(PQKBTitleCode)TC0000716765 035 $a(PQKBWorkID)10724463 035 $a(PQKB)11411149 035 $a(DE-He213)978-94-007-4719-7 035 $a(MiAaPQ)EBC971833 035 $a(PPN)168338785 035 $a(EXLCZ)992560000000091190 100 $a20120922h20122013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGlioma signaling /$fJolanta Baranska, editor 205 $a1st ed. 2013. 210 $aDordrecht $cSpringer$d2012, c2013 215 $a1 online resource (232 p.) 225 0$aAdvances in experimental medicine and biology,$x0065-2598 ;$vv. 986 300 $aDescription based upon print version of record. 311 08$a9789400747180 311 08$a9400747187 320 $aIncludes bibliographical references and index. 327 $aGlioma Signaling; Preface; Contents; Contributors; Chapter 1: Introduction to Purinergic Signalling in the Brain; 1.1 Introduction; 1.2 Purinergic Signalling in the CNS; 1.2.1 Cotransmission; 1.2.2 Glial Cells; 1.2.3 Neuron-Glial Interactions; 1.3 Purinergic Signalling in Normal Behaviour; 1.4 Purinergic Pathophysiology in the CNS, Including Gliomas; References; Chapter 2: Adenosine Signaling in Glioma Cells; 2.1 Introduction; 2.2 Adenosine Metabolism and P1 Adenosine Receptors; 2.3 A Role for Ecto-5' -Nucleotidases CD39 and CD73 in Gliomas? 327 $a2.4 Receptor-Mediated Effects of Adenosine on Glioma Cell Growth and Survival2.4.1 A 1AR-, A 2A AR-, and A 2B AR-Mediated Effects on Glioma Cells; 2.4.2 The A 3 Receptor Subtype as a New Pharmacological Target for Innovative Chemotherapic Approaches to Gliomas; 2.5 Receptor-Independent Effects of Adenosine Analogues in Glioma Cell Growth and Survival; 2.6 Conclusions and Future Perspectives; References; Chapter 3: Cross-Talk in Nucleotide Signaling in Glioma C6 Cells; 3.1 Introduction; 3.2 Properties of P2 Receptors; 3.2.1 P2X Receptors; 3.2.2 P2Y Receptors 327 $a3.3 P2Y 1 , P2Y 2 and P2Y 12 Receptor Expression and Functionality in Glioma C6 Cells3.4 Serum Withdrawal; 3.4.1 Effect on P2Y 1 and P2Y 12 Receptor Expression; 3.4.2 Effect on C6 Cell Morphology, Growth and Differentiation; 3.4.3 Effect on the P2Y 14 Receptor; 3.5 Cyclic AMP Effect on Cell Proliferation, Growth and Differentiation; 3.6 Effect of Extracellular Nucleotides on ERK1/2 and PI3K/Akt Activity: P2Y 1 / P2Y 12 Cross-Talk; 3.7 The P2X 7 Receptor; 3.8 Concluding Remarks; References; Chapter 4: Calcium Signaling in Glioma Cells - The Role of Nucleotide Receptors 327 $a4.1 Origin of the Calcium Signaling4.2 Sources of the Calcium Signal; 4.2.1 Extracellular Calcium Signal; 4.2.2 Signal Generated by Calcium Stores; 4.2.2.1 Store-Operated Calcium Signaling; 4.2.2.2 Calcium-Induced Calcium Signaling; 4.3 Calcium Signaling in Non-Excitable Glial Cells; 4.3.1 Astrocytes; 4.3.2 Microglia; 4.4 Nucleotide Receptor-Evoked Calcium Signaling in Glial Cells; 4.5 Glioma C6: A Case Study; 4.5.1 The Nature of the Signal - The Role of Nucleotide Receptors in Glioma C6 Cells; 4.6 Gliomas: The Motile Tumors, Calcium Signaling and Chemotaxis 327 $a4.6.1 The Calcium Signal in Glioma C6 Is Strongly Dependent on Actin Cytoskeleton4.7 Concluding Remarks; References; Chapter 5: Purinergic Signaling in Glioma Progression; 5.1 Introduction; 5.1.1 Molecular and Cellular Origins of Gliomas; 5.1.2 Glioma Cancer Stem Cells (CSCs); 5.1.3 Tumor Microenvironment - Key for Understanding and Targeting Gliomas; 5.2 Purinergic Signaling in Gliomas; 5.3 Ectonucleotidases; 5.3.1 Ectonucleoside Triphosphate Diphosphohydrolases (E-NTPDases); 5.3.2 Ectonucleotide Pyrophosphatase/Phosphodiesterases (E-NPPs); 5.3.3 Ecto-Alkaline Phosphatases (ALP) 327 $a5.3.4 Ecto-5' -Nucleotidase (Ecto-5' -NT/CD73) 330 $aGliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v986 606 $aGliomas 606 $aCell receptors 606 $aCellular signal transduction 606 $aBrain$xTumors 615 0$aGliomas. 615 0$aCell receptors. 615 0$aCellular signal transduction. 615 0$aBrain$xTumors. 676 $a571.6 701 $aBaranska$b Jolanta$f1969-$01751936 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437615503321 996 $aGlioma signaling$94187079 997 $aUNINA