LEADER 03631nam 2200553Ia 450 001 9910437613703321 005 20200520144314.0 010 $a3-7091-1410-1 024 7 $a10.1007/978-3-7091-1410-0 035 $a(CKB)2670000000388837 035 $a(EBL)1317537 035 $a(SSID)ssj0000924594 035 $a(PQKBManifestationID)11507807 035 $a(PQKBTitleCode)TC0000924594 035 $a(PQKBWorkID)10888297 035 $a(PQKB)11668540 035 $a(DE-He213)978-3-7091-1410-0 035 $a(MiAaPQ)EBC1317537 035 $a(PPN)170493520 035 $a(EXLCZ)992670000000388837 100 $a20111102d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHomocysteine in protein structure/function and human disease $echemical biology of homocysteine-containing proteins /$fHieronim Jakubowski 205 $a1st ed. 2013. 210 $aWien $cSpringer-Verlag$d2013 215 $a1 online resource (174 p.) 300 $aDescription based upon print version of record. 311 $a3-7091-1720-8 311 $a3-7091-1409-8 320 $aIncludes bibliographical references and index. 327 $a1. Introduction -- 2. Homocysteine. Chemical Synthesis -- Physicochemical Properties -- Quantification Methods -- Metabolic Pathways -- Clinical significance -- 3. Homocysteine Thiolactone -- Chemical Synthesis -- Physicochemical Properties -- Quantification Methods -- Biological Formation and Turnover -- Clinical Significance -- 4. N-Homocysteinylated Proteins -- Functional Consequences -- Albumin -- Fibrinogen -- Cytochrome c -- Other Proteins -- Quantification Methods -- Total N-homocysteinylation assays -- Site-specific N-homocysteinylation assays -- Formation in vivo -- Turnover to N?-Homocysteinyl-lysine -- Biological Consequences and Clinical Significance -- 5. S-Homocysteinylated Proteins -- Formation in vitro -- Functional Consequences -- Annexin -- Metallothionein -- Fibrilin, Fibronectin, Tropoelastin -- Detection in vivo -- Biological consequences -- Conclusions -- References. 330 $aExcess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. 606 $aProteins$xSynthesis 606 $aHomocysteine 615 0$aProteins$xSynthesis. 615 0$aHomocysteine. 676 $a616.1071 700 $aJakubowski$b Hieronim$01059917 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437613703321 996 $aHomocysteine in Protein Structure$92509570 997 $aUNINA