LEADER 03301nam 2200577 a 450 001 9910437613403321 005 20200520144314.0 010 $a1-283-63384-1 010 $a9786613946294 010 $a94-007-4596-6 024 7 $a10.1007/978-94-007-4596-4 035 $a(CKB)2560000000091179 035 $a(EBL)994560 035 $a(OCoLC)807986538 035 $a(SSID)ssj0000746051 035 $a(PQKBManifestationID)11930877 035 $a(PQKBTitleCode)TC0000746051 035 $a(PQKBWorkID)10859632 035 $a(PQKB)10451656 035 $a(DE-He213)978-94-007-4596-4 035 $a(MiAaPQ)EBC994560 035 $a(PPN)168338459 035 $a(EXLCZ)992560000000091179 100 $a20120424d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aModelling of GPCRs $ea practical handbook /$fAndrea Strasser, Hans-Joachim Wittmann 205 $a1st ed. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (218 p.) 300 $aDescription based upon print version of record. 311 $a94-017-8091-9 311 $a94-007-4595-8 320 $aIncludes bibliographical references and index. 327 $aPreface -- 1. Introduction -- 2. G Protein Coupled Receptors -- 3. Sequence alignment and homology modelling -- 4. Construction of ligands -- 5. Lipids -- 6. Minimization and molecular dynamics.- 7. Calculation of Gibbs energy of salvation -- 8. Special topics in GPCR research -- 9. Force fields -- 10. Thermodynamics of ligand-receptor interaction -- 11. Important LINUX commands -- Literature -- Appendix -- Index. 330 $aG protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is ? in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book ?Modelling of GPCRs ? a practical handbook? is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces  principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book. 606 $aG proteins$xReceptors 615 0$aG proteins$xReceptors. 676 $a572.696 700 $aStrasser$b Andrea$01058426 701 $aWittmann$b Hans-Joachim$01758169 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437613403321 996 $aModelling of GPCRs$94196317 997 $aUNINA