LEADER 04317nam 22006495 450 001 9910437612403321 005 20200706001437.0 010 $a1-4614-9044-8 024 7 $a10.1007/978-1-4614-9044-9 035 $a(CKB)2550000001198297 035 $a(EBL)1697831 035 $a(OCoLC)881165903 035 $a(SSID)ssj0001185995 035 $a(PQKBManifestationID)11675877 035 $a(PQKBTitleCode)TC0001185995 035 $a(PQKBWorkID)11219398 035 $a(PQKB)10242927 035 $a(DE-He213)978-1-4614-9044-9 035 $a(MiAaPQ)EBC1697831 035 $a(PPN)176100385 035 $a(EXLCZ)992550000001198297 100 $a20140123d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions$b[electronic resource] /$fedited by William J. Meggs 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer US :$cImprint: Springer,$d2013. 215 $a1 online resource (297 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-9043-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction: Irritant asthma, irritant rhinitis -- Airway Anatomy, Physiology, and Inflammation -- Reactive Airways Dysfunction Syndrome (RADS) and Irritant-Induced Asthma -- Acute Toxicity of Respiratory Irritant Exposures -- Particulate Exposure and Cardiovascular Inflammation -- Products of Combustion -- Irritant and Airborne Contact Dermatitis -- Exposure Limits -- Occupational Issues Related to Respiratory Irritants -- The Brain as a Target Organ for Allergic and Irritant Sensitivity: A Review and Suggestions for Research -- An Approach to Treating Irritant Airway Inflammation -- Summary and Research Needs -- Index. 330 $aUntoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals. This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances.  Allergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest. 606 $aPharmacology 606 $aMedicine 606 $aImmunology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aMedicine/Public Health, general$3https://scigraph.springernature.com/ontologies/product-market-codes/H00007 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aPharmacology. 615 0$aMedicine. 615 0$aImmunology. 615 14$aPharmacology/Toxicology. 615 24$aMedicine/Public Health, general. 615 24$aImmunology. 676 $a610 676 $a615 676 $a616.200471 676 $a616079 702 $aMeggs$b William J$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437612403321 996 $aThe Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions$92509567 997 $aUNINA