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010   $a3-642-27340-8
024 7 $a10.1007/978-3-642-27340-7
035   $a(CKB)2670000000533519
035   $a(EBL)1206019
035   $a(OCoLC)832325814
035   $a(SSID)ssj0000870716
035   $a(PQKBManifestationID)11461098
035   $a(PQKBTitleCode)TC0000870716
035   $a(PQKBWorkID)10818990
035   $a(PQKB)10413650
035   $a(DE-He213)978-3-642-27340-7
035   $a(MiAaPQ)EBC1206019
035   $a(PPN)169137783
035   $a(MiAaPQ)EBC4419376
035   $a(EXLCZ)992670000000533519
100   $a20130321d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aHepatitis C virus $efrom molecular virology to antiviral therapy /$fedited by Ralf Bartenschlager
205   $a1st ed. 2013.
210   $aBerlin, Heidelberg $cSpringer Berlin Heidelberg $cImprint: Springer$d2013
215   $a1 online resource (346 p.)
225 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$v369
300   $aDescription based upon print version of record.
311 08$a3-642-27339-4 
311 08$a3-642-42936-X 
327   $aThe Origin of Hepatitis C Virus -- Cell Culture Systems for Hepatitis C Virus -- Animal Models for Hepatitis C -- Hepatitis C Virus Entry -- Hepatitis C Virus Proteins: From Structure to Function -- Hepatitis C Virus RNA Translation -- Hepatitis C Virus RNA Replication -- Virion Assembly and Release -- Innate Immune Responses to Hepatitis C Virus -- Adaptive Immune Responses in Hepatitis C Virus Infection -- Liver Injury and Disease Pathogenesis in Chronic Hepatitis C -- Hepatitis C Virus-Specific Directly Acting Antiviral Drugs -- Treatment of Chronic Hepatitis C: Current and Future.
330   $aHepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
410  0$aCurrent topics in microbiology and immunology,$x0070-217X ;$v369.
606   $aHepatitis C virus
606   $aImmunology
606   $aMedical virology
615  0$aHepatitis C virus.
615  0$aImmunology.
615  0$aMedical virology.
676   $a616.3623
701   $aBartenschlager$b Ralf$01754268
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437611903321
996   $aHepatitis C virus$94190511
997   $aUNINA