LEADER 04070nam 2200577Ia 450 001 9910437611303321 005 20200520144314.0 010 $a3-642-35491-2 024 7 $a10.1007/978-3-642-35491-5 035 $a(CKB)2550000001045698 035 $a(EBL)1206081 035 $a(SSID)ssj0000879584 035 $a(PQKBManifestationID)11459104 035 $a(PQKBTitleCode)TC0000879584 035 $a(PQKBWorkID)10853552 035 $a(PQKB)11529901 035 $a(DE-He213)978-3-642-35491-5 035 $a(MiAaPQ)EBC1206081 035 $a(PPN)169138674 035 $a(EXLCZ)992550000001045698 100 $a20130312d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProteopathic seeds and neurodegenerative diseases /$fMathias Jucker, Yves Christen, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (155 p.) 225 1 $aResearch and perspectives in Alzheimer's disease 300 $aIncludes index. 311 $a3-642-44696-5 311 $a3-642-35490-4 327 $aPreface -- Widening Spectrum of Prions Causing Neurodegenerative Diseases (Stanley B. Prusiner).- b-Amyloid Fibril Structures, In Vitro and In Vivo (Robert Tycko).- Structure-Activity Relationship of Amyloids (Jason Greenwald and Roland Riek).- Seeding and Cross-seeding in Amyloid Diseases (Per Westermark and Gunilla T. Westermark).- The Prion-like Aspect of Alzheimer Pathology (Sarah K. Fritschi, Bahareh Eftekharzadeh, Giusi Manfredi, Tsuyoshi Hamaguchi, Götz Heilbronner, Amudha Nagarathinam, Franziska Langer, Yvonne S. Eisele, Lary Walker, Mathias Jucker).- Amyloid-? Transmissibility (Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Soto C).- Prion-like Properties of Assembled Tau Protein (Florence Clavaguera, Markus Tolnay, and Michel Goedert).- Accumulating Evidence Suggests that Parkinson´s Disease is a Prion-like Disorder -- Nolwen L. Rey, Elodie Angot, Christopher Dunning, Jennifer A. Steiner, Patrik Brundin).- Propagation and Replication of Misfolded SOD1: Implications for Amyotrophic Lateral Sclerosis (Anne Bertolotti) -- Development of Drugs that Target Proteopathic Seeds Will Require Measurement of Drug Mechanism in Human Brain (Peter T. Lansbury).- The Role of Functional Prions in the Persistence of Memory Storage (Eric R. Kandel, Irina Derkatch, Elias Pavlopoulos) -- Subject Index. 330 $aThe misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans, and appears to occur many years before the onset of clinical symptoms. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer?s disease, has increasingly implicated corruptive protein templating, or seeding, as a prime factor in the neurodegenerative process. The prion-like corruption of proteins also characterizes such clinically and etiologically diverse neurological disorders as Parkinson?s disease, Huntington?s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of affected proteins thus could reveal universal principles and common therapeutic targets for some of the most devastating and intractable human brain disorders. 410 0$aResearch and perspectives in Alzheimer's disease. 606 $aPrions 606 $aNervous system$xDegeneration 615 0$aPrions. 615 0$aNervous system$xDegeneration. 676 $a616.83 701 $aJucker$b M$g(Mathias)$01759774 701 $aChristen$b Yves$0155886 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437611303321 996 $aProteopathic seeds and neurodegenerative diseases$94198422 997 $aUNINA