LEADER 05271nam 22007935 450 001 9910437611103321 005 20200701133526.0 010 $a3-7091-1511-6 024 7 $a10.1007/978-3-7091-1511-4 035 $a(CKB)2550000001045973 035 $a(EBL)1206330 035 $a(SSID)ssj0000880120 035 $a(PQKBManifestationID)11475284 035 $a(PQKBTitleCode)TC0000880120 035 $a(PQKBWorkID)10895199 035 $a(PQKB)11475604 035 $a(DE-He213)978-3-7091-1511-4 035 $a(MiAaPQ)EBC1206330 035 $a(PPN)169141144 035 $a(EXLCZ)992550000001045973 100 $a20130407d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSphingolipids in Disease$b[electronic resource] /$fedited by Erich Gulbins, Irina Petrache 205 $a1st ed. 2013. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2013. 215 $a1 online resource (478 p.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v216 300 $aDescription based upon print version of record. 311 $a3-7091-1745-3 311 $a3-7091-1510-8 320 $aIncludes bibliographical references and index. 327 $aSphingolipids in Cancer: Sphingosine Kinase / Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance -- Using ASMase knockout Mice to Model Human Diseases -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer -- Sphingolipids and Response to Chemotherapy -- Lung Cancer and Lung Injury: The Dual Role of Ceramide -- Sphingolipids Role in Radiotherapy for Prostate Cancer -- Sphingolipids in Cardio-Reno-vascular diseases: Sphingolipid Metabolism and Atherosclerosis -- Cardiovascular Effects of Sphingosine-1-Phosphate S1P -- Cross-Talk between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease -- Sphingolipids in Inflammation, Infection and Lung Diseases -- Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity -- Sphingolipids in Acute Lung Injury -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases -- Ceramide in Cystic Fibrosis.- Regulation of the Sphingosine Kinase/Sphingosine 1 Phosphate Pathway -- Bacterial Infections and Ceramide -- Viral Infections and Sphingolipids -- Ceramide in Plasma Membrane Repair -- Sphingolipids and Inflammatory Diseases of the Skin -- Sphingolipids in Diabetes -- Sphingolipids in Neuro-psychiatry and Muscle Diseases: Neuronal Forms of Gaucher Disease -- Sphingolipids in Neuroinflammation -- Sphingolipids in Psychiatric Disorders and Pain Syndromes -- Role of Sphingosine-1-Phosphate in Sceletal Muscle Cell Biology. 330 $aSphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This  book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology  as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.   . 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v216 606 $aPharmacology 606 $aCardiology 606 $aCancer research 606 $aImmunology 606 $aNeurosciences 606 $aLipids 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aLipidology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14080 615 0$aPharmacology. 615 0$aCardiology. 615 0$aCancer research. 615 0$aImmunology. 615 0$aNeurosciences. 615 0$aLipids. 615 14$aPharmacology/Toxicology. 615 24$aCardiology. 615 24$aCancer Research. 615 24$aImmunology. 615 24$aNeurosciences. 615 24$aLipidology. 676 $a571.6 702 $aGulbins$b Erich$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPetrache$b Irina$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437611103321 996 $aSphingolipids in disease$91087180 997 $aUNINA