LEADER 03538nam 2200589Ia 450 001 9910437609303321 005 20200520144314.0 010 $a1-283-62255-6 010 $a9786613935007 010 $a1-4614-3676-1 024 7 $a10.1007/978-1-4614-3676-8 035 $a(CKB)2670000000245971 035 $a(EBL)994554 035 $a(OCoLC)809370153 035 $a(SSID)ssj0000738672 035 $a(PQKBManifestationID)11378516 035 $a(PQKBTitleCode)TC0000738672 035 $a(PQKBWorkID)10670905 035 $a(PQKB)10607737 035 $a(DE-He213)978-1-4614-3676-8 035 $a(MiAaPQ)EBC994554 035 $a(PPN)168298082 035 $a(EXLCZ)992670000000245971 100 $a20120921h20122013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aP53 in the clinics /$fPierre Hainaut, Magali Olivier, Klas G. Wiman, editors 210 $aNew York $cSpringer$d2012, c2013 215 $a1 online resource (356 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-3675-3 320 $aIncludes bibliographical references and index. 327 $aForeword -- p53 activities and the hallmarks of cancer -- The inheritance of p53 -- p53: Guardian of the metabolome -- The p53 family and stem cell biology -- Mutant p53-driven tumorigenesis -- Humanized p53 mouse models -- p53 models for mammary carcinogenesis -- TP53 somatic mutations: Prognostic and predictive value in human cancers -- Assessing TP53 status in human tumors - lessons from breast cancer -- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome -- TP53 gene therapy -- Upstream targets in the p53 pathway -- p53-reactivating molecules as research tools and anti-cancer drugs -- Restoring mutant p53 activity -- p53-immunotherapy of cancer -- Designing p53 trials: a surgical oncologist view -- p53 in the clinic: a pathologist view -- p53 in genetic counseling -- Index. 330 $aWith over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of  25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting ?next steps? in p53 research and applications. 606 $ap53 antioncogene 606 $ap53 protein 615 0$ap53 antioncogene. 615 0$ap53 protein. 676 $a616.994042 701 $aHainaut$b Pierre$0921264 701 $aOlivier$b Magali$01064342 701 $aWiman$b Klas G$01750786 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437609303321 996 $aP53 in the clinics$94185457 997 $aUNINA