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010   $a1-283-52913-0
010   $a9786613841582
010   $a94-007-4590-7
024 7 $a10.1007/978-94-007-4590-2
035   $a(CKB)2670000000232781
035   $a(EBL)971832
035   $a(OCoLC)804664595
035   $a(SSID)ssj0000737089
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035   $a(PQKBTitleCode)TC0000737089
035   $a(PQKBWorkID)10773713
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035   $a(DE-He213)978-94-007-4590-2
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035   $a(PPN)168338432
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100   $a20120726h20122013  uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aDNA repair of cancer stem cells /$fLesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, editors
205   $a1st ed. 2013.
210   $aDordrecht $cSpringer$d2012, c2013
215   $a1 online resource (179 p.)
300   $aDescription based upon print version of record.
311   $a94-007-9705-2 
311   $a94-007-4589-3 
320   $aIncludes bibliographical references and index.
327   $aPreface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index.
330   $aThe existence of ?cancer stem cells? (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence.  CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types. .
606   $aCancer cells
606   $aDNA repair
615  0$aCancer cells.
615  0$aDNA repair.
676   $a616.99
676   $a616.99/4071
701   $aMathews$b Lesley A$01758217
701   $aCabarcas$b Stephanie M$01758218
701   $aHurt$b Elaine M$01758219
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437607903321
996   $aDNA repair of cancer stem cells$94196376
997   $aUNINA