LEADER 04351nam  22007335  450 
001 9910437607903321
005 20200705130000.0
010   $a1-283-52913-0
010   $a9786613841582
010   $a94-007-4590-7
024 7 $a10.1007/978-94-007-4590-2
035   $a(CKB)2670000000232781
035   $a(EBL)971832
035   $a(OCoLC)804664595
035   $a(SSID)ssj0000737089
035   $a(PQKBManifestationID)11433451
035   $a(PQKBTitleCode)TC0000737089
035   $a(PQKBWorkID)10773713
035   $a(PQKB)10921722
035   $a(DE-He213)978-94-007-4590-2
035   $a(MiAaPQ)EBC971832
035   $a(PPN)168338432
035   $a(EXLCZ)992670000000232781
100   $a20120726d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aDNA Repair of Cancer Stem Cells /$fedited by Lesley A Mathews, Stephanie M Cabarcas, Elain Hurt
205   $a1st ed. 2013.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013.
215   $a1 online resource (179 p.)
300   $aDescription based upon print version of record.
311   $a94-007-9705-2 
311   $a94-007-4589-3 
320   $aIncludes bibliographical references and index.
327   $aPreface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index.
330   $aThe existence of ?cancer stem cells? (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence.  CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types. .
606   $aMedicine
606   $aMolecular biology
606   $aCancer research
606   $aStem cells
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010
615  0$aMedicine.
615  0$aMolecular biology.
615  0$aCancer research.
615  0$aStem cells.
615 14$aBiomedicine, general.
615 24$aMolecular Medicine.
615 24$aCancer Research.
615 24$aStem Cells.
676   $a616.99
676   $a616.99/4071
702   $aMathews$b Lesley A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aCabarcas$b Stephanie M$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aHurt$b Elain$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910437607903321
996   $aDNA Repair of Cancer Stem Cells$92531832
997   $aUNINA