LEADER 03994oam 2200505 450 001 9910437595203321 005 20190911103511.0 010 $a1-4471-5298-0 024 7 $a10.1007/978-1-4471-5298-9 035 $a(OCoLC)859667990 035 $a(MiFhGG)GVRL6YSD 035 $a(EXLCZ)993710000000019008 100 $a20130905d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aModels and algorithms for genome evolution /$fCedric Chauve, Nadia El-Mabrouk, Eric Tannier, editors 205 $a1st ed. 2013. 210 1$aLondon :$cSpringer,$d2013. 215 $a1 online resource (xii, 328 pages) $cillustrations (some color) 225 1 $aComputational Biology,$x1568-2684 ;$v19 300 $a"ISSN: 1568-2684." 311 $a1-4471-5297-2 320 $aIncludes bibliographical references and index. 327 $aPart I: Emergence of Standard Algorithms -- What's Behind Blast -- Forty Years of Model-Based Phylogeography -- How to Infer Ancestral Genome Features by Parsimony -- Duplication, Rearrangement and Reconciliation -- The Genesis of the DCJ Formula -- Part II: New Lights on Current Paradigms -- Large-Scale Multiple Sequence Alignment and Phylogeny Estimation -- Rearrangements in Phylogenetic Inference -- Status of Research on Insertion and Deletion Variations in the Human Population -- A Retrospective on Genomic Preprocessing for Comparative Genomics -- A Comparison of DCJ and Algebraic Distances -- Part III: Promising Directions -- Fractionation, Rearrangement, Consolidation, Reconstruction -- Error Detection and Correction of Gene Trees -- The Potential of Family-Free Genome Comparison -- Genetic History of Populations. 330 $aThis authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. Topics and features: Discusses the development of the BLAST algorithm, model-based phylogeography techniques, and the double cut and join (DCJ) distance formula Reviews the reconstruction of evolutionary features of ancestral genomes in a known phylogeny, and presents integrative models of evolution Introduces algorithms to estimate alignment and phylogeny on ultra-large datasets, and an approach for using likelihood methods with rearrangement models Examines the impact of insertion and deletion variants in human biology, evolution and health Surveys novel and recent research on genomic distance and family-free genome comparison Describes consolidation methods for reconstruction of ancestral gene orders, and error detection in gene tree construction Investigates  the genetic events recoverable from simulations of human population histories The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas. 410 0$aComputational biology. 606 $aComparative genomics 606 $aComputational biology 606 $aMolecular evolution 615 0$aComparative genomics. 615 0$aComputational biology. 615 0$aMolecular evolution. 676 $a572.860113 702 $aChauve$b Cedric 702 $aEl-Mabrouk$b Nadia 702 $aTannier$b Eric 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910437595203321 996 $aModels and Algorithms for Genome Evolution$92536726 997 $aUNINA