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100   $a20201205d2020      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAnimal Models for Endometriosis $eEvolution, Utility and Clinical Relevance /$fedited by Kathy L. Sharpe-Timms
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (VII, 111 p. 12 illus., 8 illus. in color.) 
225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v232
311   $a3-030-51855-8 
327   $aChapter 1. Introduction -- Chapter 2. Baboon model -- Chapter 3. Mechanisms of endometriosis-associated subfertility and novel therapeutic approaches discovered using a rat model -- Chapter 4. Animal models for pain or inflammation in endometriosis -- Chapter 5 Environmental endocrine disruptors and risk of endometriosis in mouse models.-Chapter 6. Deciphering the role of miRNAs in endometriosis pathophysiology using experimental endometriosis mouse models -- Chapter 7.Summation and future needs. .
330   $aThis new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility. Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.
410  0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v232
606   $aBiology$xTechnique
606   $aGynecology
606   $aPhysiology
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aReproductive health
606   $aBiological Techniques
606   $aGynecology
606   $aPhysiology
606   $aBiomedical Research
606   $aReproductive Medicine
615  0$aBiology$xTechnique.
615  0$aGynecology.
615  0$aPhysiology.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aReproductive health.
615 14$aBiological Techniques.
615 24$aGynecology.
615 24$aPhysiology.
615 24$aBiomedical Research.
615 24$aReproductive Medicine.
676   $a574.028
702   $aSharpe-Timms$b Kathy L.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910431349303321
996   $aAnimal models for endometriosis$92034084
997   $aUNINA