LEADER 02981nam 2200481 450 001 9910424644503321 005 20210227212004.0 010 $a981-15-7793-5 024 7 $a10.1007/978-981-15-7793-2 035 $a(CKB)4100000011508891 035 $a(DE-He213)978-981-15-7793-2 035 $a(MiAaPQ)EBC6371587 035 $a(PPN)269150994 035 $a(EXLCZ)994100000011508891 100 $a20210227d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUremic toxins and organ failure /$fHideyuki Saito, Takaaki Abe, editors 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (VIII, 180 p. 39 illus., 22 illus. in color.) 311 $a981-15-7792-7 320 $aIncludes bibliographical references. 327 $a1 Overview of Uremic Toxins -- 2 Review: Uremic toxins and gut microbiome -- 3 Gut microbiota and systemic uremic solute accumulation -- 4 Uremic toxin-related systemic disorders -- 5 Uremic Toxins and cardiovascular disease -- 6 Indoxyl sulfate and arteriosclerosis -- 7 Uremic Toxicity and Bone in CKD -- 8 D-serine as a novel uremic toxin -- 9 Uremic solutes and sarcopenia -- 10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries -- 11 Accumulation of uremic toxins in systemic organs and the effect of AST-120. 330 $aThis book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy. 606 $aUremia 606 $aMultiple organ failure 615 0$aUremia. 615 0$aMultiple organ failure. 676 $a616.635 702 $aSaito$b Hideyuki 702 $aAbe$b Takaaki 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910424644503321 996 $aUremic toxins and organ failure$92096626 997 $aUNINA