LEADER 02548nam 2200505 450 001 9910424637503321 005 20210327175554.0 010 $a981-15-8807-4 024 7 $a10.1007/978-981-15-8807-5 035 $a(CKB)4100000011528337 035 $a(MiAaPQ)EBC6380987 035 $a(DE-He213)978-981-15-8807-5 035 $a(PPN)260301736 035 $a(EXLCZ)994100000011528337 100 $a20210327d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCircadian pharmacokinetics /$fedited by Baojian Wu, Danyi Lu, Dong Dong 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (VII, 253 p. 59 illus., 46 illus. in color.) 311 $a981-15-8806-6 327 $aChapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy. 330 $aThis book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book. 606 $aPharmacology 606 $aPharmacy 606 $aMedicine 615 0$aPharmacology. 615 0$aPharmacy. 615 0$aMedicine. 676 $a780 702 $aWu$b Baojian 702 $aLu$b Danyi 702 $aDong$b Dong 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910424637503321 996 $aCircadian pharmacokinetics$92495865 997 $aUNINA