LEADER 02661nam 2200433 450 001 9910423654003321 005 20210302095002.0 010 $a3-030-56816-4 024 7 $a10.1007/978-3-030-56816-0 035 $a(CKB)4100000011479452 035 $a(DE-He213)978-3-030-56816-0 035 $a(MiAaPQ)EBC6362738 035 $a(PPN)258307315 035 $a(EXLCZ)994100000011479452 100 $a20210302d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDesign for durability and performance density /$fHani Ali Arafa 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (XVII, 229 p. 131 illus.) 311 $a3-030-56815-6 327 $aIntroductory Definitions -- Managing Reactive Loads -- Mutually Counteractive Loads at High Speed -- Subtle and Obscure Loading Sources -- Interface Sliding, Loading, and Wear -- Elastic Deformation and Microslip Issues -- Assembly Over Mobile Interfaces -- Proper Allocation of Functions -- Gearing Design for High Power Density -- High Power/Torque-Density Devices -- Hydraulic Power Density -- Megawatt-scale Fluid Power -- Energy Retrieval, Storage, and Release -- Multi-Attribute Designs. 330 $aThis book is about mechanical design engineering, in particular design for mechanical system durability and performance density. It explains mechanical design issues in application areas such as multi-megawatt fluid power transmission, and provides potential solutions. Design for Durability and Performance Density includes five real-world case studies which help to identify the root cause of problems and failure cases encountered in industry and in the oil field. It suggests remedies for the ones that could be solved, and includes sample calculations and worked examples to quantify the extent of problems where necessary. This book will be of use to mechanical engineering students, as well as design and application engineers helping them to learn how things could be designed the wrong way, and how old experience could prevent novice mistakes, to avoid being tempted into any of the various subtle design pitfalls and confronting their consequences. . 606 $aEngineering design 615 0$aEngineering design. 676 $a620.0042 700 $aArafa$b Hani Ali$01058228 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910423654003321 996 $aDesign for durability and performance density$92497965 997 $aUNINA LEADER 05678nam 22006734a 450 001 9911019867503321 005 20200520144314.0 010 $a9786610468409 010 $a9781280468407 010 $a1280468408 010 $a9780470037232 010 $a0470037237 010 $a9780470037225 010 $a0470037229 035 $a(CKB)1000000000355057 035 $a(EBL)261336 035 $a(OCoLC)475976820 035 $a(SSID)ssj0000127775 035 $a(PQKBManifestationID)11148052 035 $a(PQKBTitleCode)TC0000127775 035 $a(PQKBWorkID)10052107 035 $a(PQKB)10597649 035 $a(MiAaPQ)EBC261336 035 $a(Perlego)2756748 035 $a(EXLCZ)991000000000355057 100 $a20051122d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aComputer applications in pharmaceutical research and development /$f[edited by] Sean Ekins 210 $aHoboken, N.J. $cWiley-Interscience$dc2006 215 $a1 online resource (840 p.) 225 1 $aWiley series in drug discovery and development 300 $aDescription based upon print version of record. 311 08$a9780471737797 311 08$a0471737798 320 $aIncludes bibliographical references and index. 327 $aThe history of computers in pharmaceutical research and development: a narrative / Donald B. Boyd and Max M. Marsh -- Computers as data analysis and data management tools in preclinical development / Weiyong Li and Kenneth Banks -- Statistical modeling in pharmaceutical research and development / Andrea de Gaetano ... [et al.] -- Drug discovery from historic herbal texts / Eric J. Buenz -- Contextualizing the impact of bioinformatics on preclinical drug and vaccine discovery / Darren R. Flower -- Systems approaches for pharmaceutical research and development / Sean Ekins and Craig Giroux -- Information management-biodata in life sciences / Richard K. Scott and Anthony Parsons -- Chemoinformatics techniques for processing chemical structure databases / Valerie J. Gillet and Peter Willett -- Electronic laboratory notebooks / Alfred Nehme and Robert A. Scoffin -- Strategies for using information effectively in early-stage drug discovery / David J. Wild -- Improving the pharmaceutical R&D process: how simulation can support management decision making / Andrew Chadwick ... [et al.] -- 327 $aComputers and protein crystallography / David J. Edwards and Roderick E. Hubbard -- Computers, cheminformatics, and the medicinal chemist / Weifan Zheng and Michael Jones -- The challenges of making useful protein-ligand free energy predictions for drug discovery / Jun Shimada -- Computer algorithms for selecting molecule libraries for synthesis / Konstantin V. Balakin, Nikolay P. Savchuk, and Alex Kiselyov -- Success stories of computer-aided design / Hugo Kubinyi -- Pharmaceutical research and development productivity: can software help? / Christophe Lambert and S. Stanley Young -- Computer methods for predicting drug metabolism / Sean Ekins -- Computers in toxicology and risk assessment / John C. Dearden -- Computational modeling of drug disposition / Cheng Chang and Peter W. Swaan -- Computer simulations in pharmacokinetics and pharmacodynamics: rediscovering systems physiology in the 21st century / Paolo Vicini -- Predictive models for better decisions from understanding physiology to optimizing trial design / James R. Bosley, Jr -- 327 $aMaking pharmaceutical development more efficient / Michael Rosenberg and Richard Farris -- Use of interactive software in medical decision making / Renee J. Goldberg Arnold -- Clinical data collection and management / Mazen Abdellatif -- Regulation of computer systems / Sandy Weinberg -- A new paradigm for analyzing adverse drug events / Ana Szarfman, Jonathan G. Levine and Joseph M. Tonning -- Computers in pharmaceutical formulation / Raymond C. Rowe and Elizabeth A. Colbourn -- Legal protection of innovative uses of computers in R&D / Robert Harrison -- The ethics of computing in pharmaceutical research / Matthew K. McGowan and Richard J. McGowan -- The UltraLink: an expert system for contextual hyperlinking in knowledge management / Martin Romacker ... [et al.] -- Powerful, predictive and pervasive: the future of computers in the pharmaceutical industry / Nick Davies, Heather Ahlborn, Stuart Henderson. 330 $aA unique, holistic approach covering all functions and phases of pharmaceutical research and developmentWhile there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers read 410 0$aWiley series in drug discovery and development. 606 $aPharmacy$xData processing 606 $aPharmacology$xData processing 606 $aPharmaceutical industry$xData processing 615 0$aPharmacy$xData processing. 615 0$aPharmacology$xData processing. 615 0$aPharmaceutical industry$xData processing. 676 $a615/.10285 701 $aEkins$b Sean$0927740 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019867503321 996 $aComputer applications in pharmaceutical research and development$94423058 997 $aUNINA