LEADER 04297nam 2200433 450 001 9910420949903321 005 20210219101713.0 010 $a3-030-53868-0 024 7 $a10.1007/978-3-030-53868-2 035 $a(CKB)4100000011457761 035 $a(DE-He213)978-3-030-53868-2 035 $a(MiAaPQ)EBC6355545 035 $a(PPN)250223368 035 $a(EXLCZ)994100000011457761 100 $a20210219d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDamage-associated molecular patterns in human diseases$hVolume 2$iDanger signals as diagnostics, prognostics, and therapeutic targets /$fWalter Gottlieb Land 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (XXXIX, 629 p. 45 illus. in color.) 311 $a3-030-53867-2 327 $aPart I. Prologue -- Perspectives of the Danger/Injury Model in Immunology -- Part II. A Select, Clinically Oriented Update of Topics Presented in ?Damage-Associated Molecular Patterns in Human Diseases?; Volume 1: Injury-Induced Innate Immune Responses -- Pattern Recognition Molecules -- The Growing World of DAMPs -- The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation -- DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis -- Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases -- DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics -- DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma -- Solid Organ Injury -- Atherosclerosis -- Cerebro - Cardiovascular Diseases -- Part IV. Epilogue -- The ?DAMPome? as a Key Player in the Pathogenesis of Human Diseases. 330 $aThis book is a continuance of the topic: ?DAMPs in Human Diseases?, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (?SAMPs?) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses . 606 $aWounds and injuries$xImmunological aspects 615 0$aWounds and injuries$xImmunological aspects. 676 $a617.1 700 $aLand$b W$g(Walter),$0909257 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910420949903321 996 $aDamage-associated molecular patterns in human diseases$92034040 997 $aUNINA