LEADER 04318nam 22007215 450 001 9910416110403321 005 20220502104347.0 010 $a981-15-5815-9 024 7 $a10.1007/978-981-15-5815-3 035 $a(CKB)4100000011325629 035 $a(DE-He213)978-981-15-5815-3 035 $a(MiAaPQ)EBC6268621 035 $a(PPN)260301337 035 $a(EXLCZ)994100000011325629 100 $a20200703d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGanglioside Biochemistry$b[electronic resource] /$fby Cheorl-Ho Kim 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (XVI, 214 p. 57 illus., 48 illus. in color.) 311 $a981-15-5814-0 327 $aPreface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates. 330 $aThis book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies. 606 $aGene expression 606 $aCancer research 606 $aGenetics 606 $aBiochemistry 606 $aCell membranes  606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aGenetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32000 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 606 $aBioquímica$2thub 606 $aCàncer$2thub 606 $aExpressió gènica$2thub 608 $aLlibres electrònics$2thub 615 0$aGene expression. 615 0$aCancer research. 615 0$aGenetics. 615 0$aBiochemistry. 615 0$aCell membranes . 615 14$aGene Expression. 615 24$aCancer Research. 615 24$aGenetics and Genomics. 615 24$aBiochemistry, general. 615 24$aMembrane Biology. 615 7$aBioquímica 615 7$aCàncer 615 7$aExpressió gènica 676 $a596.0188 700 $aKim$b Cheorl-Ho$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062709 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416110403321 996 $aGanglioside Biochemistry$92542143 997 $aUNINA