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010   $a981-15-5815-9
024 7 $a10.1007/978-981-15-5815-3
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035   $a(DE-He213)978-981-15-5815-3
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100   $a20200703d2020      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aGanglioside Biochemistry /$fby Cheorl-Ho Kim
205   $a1st ed. 2020.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2020.
215   $a1 online resource (XVI, 214 p. 57 illus., 48 illus. in color.)
311 08$a981-15-5814-0 
327   $aPreface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates.
330   $aThis book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
606   $aMolecular genetics
606   $aCancer
606   $aGenetics
606   $aBiochemistry
606   $aBiological transport
606   $aCell membranes
606   $aMolecular Genetics
606   $aCancer Biology
606   $aGenetics and Genomics
606   $aBiochemistry
606   $aMembrane Trafficking
615  0$aMolecular genetics.
615  0$aCancer.
615  0$aGenetics.
615  0$aBiochemistry.
615  0$aBiological transport.
615  0$aCell membranes.
615 14$aMolecular Genetics.
615 24$aCancer Biology.
615 24$aGenetics and Genomics.
615 24$aBiochemistry.
615 24$aMembrane Trafficking.
676   $a596.0188
700   $aKim$b Cheorl-Ho$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062709
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910416110403321
996   $aGanglioside Biochemistry$92542143
997   $aUNINA