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100   $a20200713d2020      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDrug Discovery and Evaluation: Methods in Clinical Pharmacology /$fedited by Franz J. Hock, Michael R. Gralinski
205   $a2nd ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (249 illus., 179 illus. in color. eReference.)
225 1 $aSpringer reference
300   $aIncludes index.
311   $a3-319-68863-4 
330   $aThis is the second edition of a well-received book in the series ?Drug Discovery and Evaluation? The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: ?Methods in Clinical Pharmacology". For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.
410  0$aSpringer reference.
606   $aPharmacology
606   $aMedical biochemistry
606   $aPharmacotherapy
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005
606   $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000
606   $aFarmacologia$2thub
608   $aLlibres electrònics$2thub
615  0$aPharmacology.
615  0$aMedical biochemistry.
615  0$aPharmacotherapy.
615 14$aPharmacology/Toxicology.
615 24$aMedical Biochemistry.
615 24$aPharmacotherapy.
615  7$aFarmacologia
676   $a615.19
702   $aHock$b Franz J$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGralinski$b Michael R$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910416109203321
996   $aDrug Discovery and Evaluation: Methods in Clinical Pharmacology$92513355
997   $aUNINA