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035   $a(DE-He213)978-3-030-50160-0
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100   $a20200716d2020      u|             0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aMolecular Mechanisms of Retina Pathology and Ways of its Correction$b[electronic resource] /$fby Svetlana Trofimova
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (VI, 90 p. 17 illus., 11 illus. in color.)
311   $a3-030-50159-0 
327   $aChapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.
330   $aThis book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patient?s vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.
606   $aMedicine
606   $aGeriatrics
606   $aOphthalmology
606   $aPathology
606   $aCell biology
606   $aPharmacy
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
606   $aGeriatrics/Gerontology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33150
606   $aOphthalmology$3https://scigraph.springernature.com/ontologies/product-market-codes/H44004
606   $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aPharmacy$3https://scigraph.springernature.com/ontologies/product-market-codes/F00008
606   $aOftalmopaties$2thub
606   $aRetina$2thub
606   $aBiologia molecular$2thub
608   $aLlibres electrònics$2thub
615  0$aMedicine.
615  0$aGeriatrics.
615  0$aOphthalmology.
615  0$aPathology.
615  0$aCell biology.
615  0$aPharmacy.
615 14$aBiomedicine, general.
615 24$aGeriatrics/Gerontology.
615 24$aOphthalmology.
615 24$aPathology.
615 24$aCell Biology.
615 24$aPharmacy.
615  7$aOftalmopaties
615  7$aRetina
615  7$aBiologia molecular
676   $a617.7
700   $aTrofimova$b Svetlana$4aut$4http://id.loc.gov/vocabulary/relators/aut$01057954
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910416108003321
996   $aMolecular Mechanisms of Retina Pathology and Ways of its Correction$92495861
997   $aUNINA