LEADER 05446oam 2200721I 450 001 9910785742203321 005 20230801224406.0 010 $a1-136-00137-9 010 $a1-283-60624-0 010 $a9786613918697 010 $a1-136-00138-7 010 $a0-12-385197-1 024 7 $a10.4324/9780123851970 035 $a(CKB)2670000000242208 035 $a(EBL)1024497 035 $a(OCoLC)811505686 035 $a(SSID)ssj0000711869 035 $a(PQKBManifestationID)11433523 035 $a(PQKBTitleCode)TC0000711869 035 $a(PQKBWorkID)10722071 035 $a(PQKB)11189971 035 $a(OCoLC)810924665 035 $a(MiAaPQ)EBC1024497 035 $a(Au-PeEL)EBL1024497 035 $a(CaPaEBR)ebr10603411 035 $a(CaONFJC)MIL391869 035 $a(OCoLC)900233878 035 $a(FINmELB)ELB133041 035 $a(EXLCZ)992670000000242208 100 $a20180706d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSustainable hospitality and tourism as motors for development $ecase studies from developing regions of the world /$fedited by Philip Sloan, Claudia Simons-Kaufman and Willy Legrand 210 1$aNew York :$cRoutledge,$d2012. 215 $a1 online resource (497 p.) 300 $aDescription based upon print version of record. 311 $a1-138-08150-7 311 $a0-12-385196-3 320 $aIncludes bibliographical references and index. 327 $aCover; Title; Copyright; Contents; List of figures and tables; Contributors; Foreword; Editors' preface; Editors' biography; An overview of the book; How to use this book; 1 Introduction: scarcity of natural resources or 'Cockaigne'?; Part 1: What do we mean by development?; Part 2: Sustainability in tourism and hospitality; 2 The case of Inkaterra: pioneering ecotourism in Peru; 3 Integrated circuits as a tool for the development of sustainable tourism in the Amazon; 4 Bringing sustainability to the Brazilian hotel industry 327 $a5 Preferences regarding restoration and development at Copan Archeological Park, Honduras: linkages between setting, visitor experiences and sustainability6 Mamiraua?: community based ecotourism in a sustainable development reserve in the Amazon Basin; 7 Ecuador: Huaorani Ecolodge; 8 Tourism in the Peruvian Amazon: experiences of a private-communal partnership; 9 Key issues and challenges to the development of community-based ecotourism in Guatemala; 10 Tourism cluster among livestock: the case of Bonito (MS), Brazil; 11 Diversified nature tourism on St. Vincent 327 $a12 Can ecotourism support coral reef conservation? Experiences of Chumbe Island Coral Park Ltd in Zanzibar/Tanzania13 Blossoms & Butterflies, Waterfalls & Dragonflies: integrating insects in the hospitality and tourism industries through Swarm supposition; 14 Sustainable tourism development in the Masai Mara National Reserve Kenya: stakeholder perspectives; 15 Ecotourism in vulnerable regions: opportunities and obstacles to development - the case of Cantanhez, Guine?-Bissau; 16 Minimission-Tourism in Ethiopia: a new subspecies of sustainable volunteer tourism?; 17 Botswana: The Selinda Reserve 327 $a18 Sustainable development of a remote tourist destination: the case of Soomaa National Park, Estonia19 Challenges in rural ethnic tourism development: a case study from Yunnan, China; 20 Hotel Management education in Bhutan: teaching sustainable principles; 21 Investigating potential benefits of proposed eco-retrofits to an existing tourist lodge in The Sundarbans, India; 22 Urban green parks: sustainable tourism, biodiversity and quality of life: a case study; 23 Philippine sustainable tourism initiatives: issues and challenges 327 $a24 Turtle night watch nature tourism: sharing benefits to sustain local community and Sea Turtles in Rekawa sanctuary, Sri Lanka25 Six Senses Hideaway, Ninh Van Bay, Vietnam: where luxury meets sustainable tourism; 26 Tourist destinations with planned interventions: the success of Kumily in Kerala, India; 27 The development and promotion of guidelines for organic farms for sustainable tourism; Glossary; Index 330 $aIt is now widely agreed that the climate is changing, global resources are diminishing and biodiversity is suffering. Developing countries - many of them considered by the World Tourism Organization to be 'Top Emerging Tourism Destinations' (UNWTO, 2009) - are already suffering the full frontal effect of environmental degradation. The challenge for developing countries is a triple-edged sword, how can economic prosperity be achieved without the perpetual depletion of nature's reserves, the destruction of rural habitat and the dislocation of traditional societies? Many emerging nations are l 606 $aSustainable tourism$zDeveloping countries$vCase studies 606 $aHospitality industry$zDeveloping countries$vCase studies 615 0$aSustainable tourism 615 0$aHospitality industry 676 $a338.4/791091724 701 $aLegrand$b Willy$0987072 701 $aSimons-Kaufman$b Claudia$01512230 701 $aSloan$b Philip$01179702 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910785742203321 996 $aSustainable hospitality and tourism as motors for development$93746028 997 $aUNINA LEADER 03545nam 22005055 450 001 9910416107703321 005 20250610110203.0 010 $a3-030-48283-9 024 7 $a10.1007/978-3-030-48283-1 035 $a(CKB)4100000011343506 035 $a(DE-He213)978-3-030-48283-1 035 $a(MiAaPQ)EBC6273633 035 $a(PPN)260302473 035 $a(MiAaPQ)EBC6264054 035 $a(MiAaPQ)EBC29090359 035 $a(EXLCZ)994100000011343506 100 $a20200714d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNext Generation Kinase Inhibitors $eMoving Beyond the ATP Binding/Catalytic Sites /$fedited by Paul Shapiro 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XII, 217 p. 59 illus., 56 illus. in color.) 311 08$a3-030-48282-0 327 $aChapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index. 330 $aProtein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. . 606 $aCancer$xResearch 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aProteïnes quinases$2thub 608 $aLlibres electrònics$2thub 615 0$aCancer$xResearch. 615 14$aCancer Research. 615 7$aProteïnes quinases. 676 $a572.792 702 $aShapiro$b Paul$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416107703321 996 $aNext Generation Kinase Inhibitors$92147580 997 $aUNINA