LEADER 04937nam 22007095 450 001 9910416102403321 005 20220422104756.0 010 $a3-030-43085-5 024 7 $a10.1007/978-3-030-43085-6 035 $a(CKB)4100000011372925 035 $a(DE-He213)978-3-030-43085-6 035 $a(MiAaPQ)EBC6296619 035 $a(PPN)250217546 035 $a(EXLCZ)994100000011372925 100 $a20200807d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCurrent Advances in the Science of Osteosarcoma $eResearch Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models /$fedited by Eugenie S. Kleinerman, Richard Gorlick 205 $a2nd ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 233 p. 34 illus., 23 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1258 311 $a3-030-43084-7 327 $aThe genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index. 330 $aThis thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1258 606 $aCancer$xResearch 606 $aMedical microbiology 606 $aCytology 606 $aPediatrics 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aPediatrics$3https://scigraph.springernature.com/ontologies/product-market-codes/H49006 606 $aOsteosarcoma$2thub 606 $aSarcoma$2thub 606 $aInvestigació mèdica$2thub 608 $aLlibres electrònics$2thub 615 0$aCancer$xResearch. 615 0$aMedical microbiology. 615 0$aCytology. 615 0$aPediatrics. 615 14$aCancer Research. 615 24$aMedical Microbiology. 615 24$aCell Biology. 615 24$aPediatrics. 615 7$aOsteosarcoma 615 7$aSarcoma. 615 7$aInvestigació mèdica 676 $a616.99471 702 $aKleinerman$b Eugenie S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGorlick$b Richard$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416102403321 996 $aCurrent Advances in the Science of Osteosarcoma$92140631 997 $aUNINA