LEADER 04544nam 22006855 450 001 9910416101703321 005 20240424174919.0 010 $a3-030-50480-8 024 7 $a10.1007/978-3-030-50480-9 035 $a(CKB)4100000011373032 035 $a(DE-He213)978-3-030-50480-9 035 $a(MiAaPQ)EBC6276165 035 $a(PPN)250214822 035 $a(EXLCZ)994100000011373032 100 $a20200803d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe M2 Macrophage$b[electronic resource] /$fby Tamás Röszer 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 224 p. 56 illus., 49 illus. in color.) 225 1 $aProgress in Inflammation Research,$x0379-0363 ;$v86 311 0 $a3-030-50479-4 327 $aChapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork -- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates -- Chapter 3. Evolution of M2 macrophage functions in chordates -- Chapter 4. Signal mechanisms of M2 macrophage activation -- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches -- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity -- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system -- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs -- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system -- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions. 330 $aMacrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered. 410 0$aProgress in Inflammation Research,$x0379-0363 ;$v86 606 $aImmunology 606 $aCell biology 606 $aLipids 606 $aCommunicable diseases 606 $aInfection 606 $aHuman physiology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aLipidology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14080 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 615 0$aImmunology. 615 0$aCell biology. 615 0$aLipids. 615 0$aCommunicable diseases. 615 0$aInfection. 615 0$aHuman physiology. 615 14$aImmunology. 615 24$aCell Biology. 615 24$aLipidology. 615 24$aInfectious Diseases. 615 24$aHuman Physiology. 676 $a571.9685 700 $aRöszer$b Tamás$4aut$4http://id.loc.gov/vocabulary/relators/aut$0904205 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416101703321 996 $aThe M2 Macrophage$92021813 997 $aUNINA