LEADER 03856oam 22005655 450 001 9910416101203321 005 20240125232801.0 010 $a3-030-52123-0 024 7 $a10.1007/978-3-030-52123-3 035 $a(CKB)4100000011384206 035 $a(DE-He213)978-3-030-52123-3 035 $a(MiAaPQ)EBC6304311 035 $a(PPN)25021492X 035 $a(EXLCZ)994100000011384206 100 $a20200814d2020 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBacterial type III protein secretion systems /$fedited by Samuel Wagner, Jorge E. Galan 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VIII, 230 p.) $c1 illus 225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v427 300 $aIncludes index. 311 0 $a3-030-52122-2 327 $aIntroduction -- Evolution of type III secretion systems -- Transcriptional and post-transcriptional regulatory mechanisms controlling type III secretion -- Assembly of type III secretion machines -- Structure of the type III secretion needle complex -- Structure and assembly of filamentous structures associated with type III secretion machines -- Structure and function of the type III secretion-associated sorting platform -- Molecular organization and assembly of the protein export apparatus -- Export mechanisms and energy transduction in type III secretion machines -- Needle length control and substrate switching in type III secretion machines -- The tip complex: sensing the host cell -- Chaperones and targeting mechanisms. . 330 $aOne of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen?s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis. 410 0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v427 606 $aBacteria$xPhysiology 606 $aPathogenic bacteria 606 $aBacteriologia$2thub 606 $aMicrobiologia mèdica$2thub 608 $aLlibres electrònics$2thub 615 0$aBacteria$xPhysiology. 615 0$aPathogenic bacteria. 615 7$aBacteriologia 615 7$aMicrobiologia mèdica 676 $a616.014 676 $a579.3165 702 $aWagner$b Samuel$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGalan$b Jorge E$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910416101203321 996 $aBacterial Type III Protein Secretion Systems$92513086 997 $aUNINA